LONP-1 aids propagation of deleterious mtDNA

The integrity of the mitochondrial genome (mitochondrial DNA) is crucial for energy synthesis in all complex life. A study now reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that preferentially propagates genomes carrying deleterious mutations.

Automated summary

The integrity of mitochondrial DNA is crucial for energy synthesis. A recent study reveals a vicious cycle of mtDNA replication within dysfunctional mitochondria that propagates genomes with deleterious mutations.