☆ 4.8 Article

Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

NATURE (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Cell Biology

The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

Izumi Kimura et al.

Summary: This study reveals the increased infectivity and antibody evasion mechanism of the SARS-CoV-2 Lambda variant using pseudoviruses. The spike protein of the Lambda variant is more infectious than other variants due to specific mutations, and the RSYLTPGD246-253N mutation is responsible for antibody evasion and enhanced infection.

CELL REPORTS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Spike mutation D614G alters SARS-CoV-2 fitness

Jessica A. Plante et al.

Summary: The D614G substitution in the SARS-CoV-2 spike protein enhances viral replication and infectivity in human lung epithelial cells, primary airway tissues, and hamsters. This variant may increase transmission in the upper respiratory tract and doesn't seem to significantly reduce vaccine efficacy. Further research on therapeutic antibodies targeting the circulating G614 virus is recommended.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Erik Volz et al.

Summary: The study suggests a positive selection for the SARS-CoV-2 spike protein variant D614G in the UK, but no evidence of differences in COVID-19 mortality or clinical severity in patients infected with this variant. 614G is associated with higher viral load and younger age of patients compared to 614D.

CELL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Bryan A. Johnson et al.

Summary: The genetic mutation in SARS-CoV-2 resulted in better fitness in some cells but lower replication capacity in human respiratory cell lines. Despite reducing disease symptoms, the Delta PRRA mutant provided protection against rechallenge with the wildtype SARS-CoV-2.

NATURE (2021)

添加到收藏夹

Review Microbiology

The variant gambit: COVID-19's next move

Jessica A. Plante et al.

Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.

CELL HOST & MICROBE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 spike D614G change enhances replication and transmission

Bin Zhou et al.

Summary: Research has shown that the D614G substitution in the spike protein of SARS-CoV-2 leads to increased binding and replication potential in humans, as well as significantly higher replication and transmissibility in different animal models, providing an explanation for the global prevalence of this variant in the COVID-19 pandemic.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity

Seiya Ozono et al.

Summary: The naturally occurring mutations of SARS-CoV-2 spike protein can affect cell entry, with the D614G mutation resulting in increased cell entry and maintaining susceptibility to neutralization by antisera against prototypic viruses. Further global surveillance is needed to understand the transmissibility of SARS-CoV-2 among humans.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biology

Twelve years of SAMtools and BCFtools

Petr Danecek et al.

Summary: SAMtools and BCFtools are widely used tools for processing high-throughput sequencing data, with a history of 12 years of continuous development and improvement. These packages have been utilized in various software projects and genomic pipelines and are freely available on GitHub.

GIGASCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes

Satoshi Ikegame et al.

Summary: Measles virus (MeV) is resurgent and can establish chronic latent infections in the brain, leading to fatal conditions like SSPE or MIBE. Mutations in the F gene may result in hyperfusogenic phenotypes, allowing for efficient spread in neurons, but how these mutants are selected and their advantage in neuronal spread remains unclear. Screening of MeV-F mutants has identified hyperfusogenic mutations, providing a valuable resource for future studies on MeV neuropathogenesis and paramyxovirus F regulation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Cell Biology

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

Shiho Torii et al.

Summary: A PCR-based, bacterium-free method has been developed to generate SARS-CoV-2 infectious clones, allowing for a better understanding of the virus through the construction of reporter and mutant viruses.

CELL REPORTS (2021)

添加到收藏夹

Article Microbiology

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

Thomas P. Peacock et al.

Summary: Efficient transmission of SARS-CoV-2 among infected ferrets is dependent on a functional furin cleavage site in the spike protein. The virus has a selective advantage in lung cells and primary human airway epithelial cells due to a polybasic insertion, but replication may be impaired in certain cell lines.

NATURE MICROBIOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Tackling COVID-19 with neutralizing monoclonal antibodies

Davide Corti et al.

Summary: Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity, and infectious diseases. Lessons learned from the COVID-19 pandemic have paved the way for the development of more monoclonal antibody-based therapeutics.

CELL (2021)

添加到收藏夹

Article Microbiology

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

Chihiro Motozono et al.

Summary: Research has shown that certain mutations in SARS-CoV-2 variants can escape HLA-restricted cellular immunity, increase affinity for host cells, promote viral replication, and potentially affect the evolution of viral phenotypes.

CELL HOST & MICROBE (2021)

添加到收藏夹

Letter Medicine, General & Internal

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination

Emma C. Wall et al.

LANCET (2021)

添加到收藏夹

Letter Medicine, General & Internal

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

Aziz Sheikh et al.

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

添加到收藏夹

Letter Biochemistry & Molecular Biology

SARS-CoV-2 variants of concern are emerging in India

Jasdeep Singh et al.

NATURE MEDICINE (2021)

添加到收藏夹

Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Petra Mlcochova et al.

Summary: The B.1.617.2 (Delta) variant of SARS-CoV-2 has lower sensitivity to antibodies and higher replication efficiency compared to other lineages, which may contribute to its dominance and reduced vaccine effectiveness, highlighting the need for continued infection control measures post-vaccination.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era

Bui Quang Minh et al.

MOLECULAR BIOLOGY AND EVOLUTION (2020)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV)

Michael Chung et al.

RADIOLOGY (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Tracy: basecalling, alignment, assembly and deconvolution of sanger chromatogram trace files

Tobias Rausch et al.

BMC GENOMICS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells

Shutoku Matsuyama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA - Secondary Publication

Scott Simpson et al.

JOURNAL OF THORACIC IMAGING (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

Bette Korber et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Super-rapid quantitation of the production of HIV-1 harboring a luminescent peptide tag

Seiya Ozono et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

Leonid Yurkovetskiy et al.

CELL (2020)

添加到收藏夹

Article Microbiology

A Simplified Quantitative Real-Time PCR Assay for Monitoring SARS-CoV-2 Growth in Cell Culture

Christian Shema Mugisha et al.

MSPHERE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Yixuan J. Hou et al.

SCIENCE (2020)

添加到收藏夹

Article Biotechnology & Applied Microbiology

HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1

Terumasa Ikeda et al.

JOURNAL OF GENERAL VIROLOGY (2019)

添加到收藏夹

Article Virology

Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid

Tahmina Sultana et al.

JOURNAL OF VIROLOGY (2019)

添加到收藏夹

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

添加到收藏夹

Article Microbiology

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

Terumasa Ikeda et al.

PLOS PATHOGENS (2018)

添加到收藏夹

Article Virology

Mutant Fusion Proteins with Enhanced Fusion Activity Promote Measles Virus Spread in Human Neuronal Cells and Brains of Suckling Hamsters

Shumpei Watanabe et al.

JOURNAL OF VIROLOGY (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

Kazutaka Katoh et al.

MOLECULAR BIOLOGY AND EVOLUTION (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3

Pablo Cingolani et al.

FLY (2012)

添加到收藏夹

Article Biochemical Research Methods

Fast and accurate long-read alignment with Burrows-Wheeler transform

Heng Li et al.

BIOINFORMATICS (2010)

添加到收藏夹

Review Virology

The V1-V3 region of a brain-derived HIV-1 envelope glycoprotein determines macrophage tropism, low CD4 dependence, increased fusogenicity and altered sensitivity to entry inhibitors

Fiorella Rossi et al.

RETROVIROLOGY (2008)

添加到收藏夹

Article Virology

Asn 362 in gp120 contributes to enhanced fusogenicity by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with AIDS

Jasminka Sterjovski et al.

RETROVIROLOGY (2007)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.