期刊
NATURE
卷 602, 期 7896, 页码 300-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41586-021-04266-9
关键词
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资金
- AMED Research Program on Emerging and Re-emerging Infectious Diseases [20fk0108163, 20fk0108401, 21fk0108617, 19fk0108113, JP20fk0108412, 20fk0108146, 20fk0108270, 20fk0108413, 20fk0108451]
- AMED Research Program on HIV/AIDS [21fk0410033, 21fk0410039]
- AMED Japan Program for Infectious Diseases Research and Infrastructure [20wm0325009, 21wm0325009, 21wm0125002]
- JST A-STEP [JPMJTM20SL]
- JST SICORP (e-ASIA) [JPMJSC20U1]
- JST SICORP [JPMJSC21U5]
- JST CREST [JPMJCR20H6, JPMJCR20H4]
- JSPS KAKENHI [19K06382, 18K07156, 21K07060]
- Scientific Research B [18H02662, 21H02737]
- JSPS Fund for the Promotion of Joint International Research (Fostering Joint International Research) [18KK0447]
- JSPS Core-to-Core Program [JPJSCCA20190008]
- JSPS Research Fellow [DC1 19J20488]
- JSPS Leading Initiative for Excellent Young Researchers (LEADER)
- ONO Medical Research Foundation
- Ichiro Kanehara Foundation
- Lotte Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Daiichi Sankyo Foundation of Life Science
- Sumitomo Foundation
- Uehara Foundation
- Takeda Science Foundation
- Tokyo Biochemical Research Foundation
- Mitsubishi Foundation
- Shin-Nihon Foundation of Advanced Medical Research
- Tsuchiya Foundation
- Research Institute for Microbial Diseases, Osaka University
- Kumamoto University COVID-19 Research Projects (AMABIE)
- Intercontinental Research and Educational Platform Aiming for Eradication of HIV/AIDS
- Joint Usage/Research Center program of Institute for Frontier Life and Medical Sciences, Kyoto University
- Grants-in-Aid for Scientific Research [21K07060, 21H02737, 19K06382, 18K07156, 18KK0447, 18H02662] Funding Source: KAKEN
During the COVID-19 pandemic, the B.1.617.2/Delta variant has been found to be highly fusogenic and more pathogenic in infected hamsters compared to prototypic SARS-CoV-2. The P681R mutation in the spike protein of this variant enhances viral fusogenicity and pathogenicity.
During the current coronavirus disease 2019 (COVID-19) pandemic, a variety of mutations have accumulated in the viral genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and, at the time of writing, four variants of concern are considered to be potentially hazardous to human society(1). The recently emerged B.1.617.2/Delta variant of concern is closely associated with the COVID-19 surge that occurred in India in the spring of 2021 (ref.(2)). However, the virological properties of B.1.617.2/Delta remain unclear. Here we show that the B.1.617.2/Delta variant is highly fusogenic and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters. The P681R mutation in the spike protein, which is highly conserved in this lineage, facilitates cleavage of the spike protein and enhances viral fusogenicity. Moreover, we demonstrate that the P681R-bearing virus exhibits higher pathogenicity compared with its parental virus. Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity.
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