期刊
INFECTION GENETICS AND EVOLUTION
卷 43, 期 -, 页码 130-134出版社
ELSEVIER
DOI: 10.1016/j.meegid.2016.05.021
关键词
Dengue virus type 1; Lineages; Genotype V; Phylodynamics; Phylogeography; Phylogeny
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) Universal CNPq [14/2013, 483028/2013-4]
- Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG) Chamada Publica FAPEG [005/2012, 201210267001064]
- FAPEG scholarships [003/2013, 201310267000274]
Dengue virus type 1 (DENV-1) was the first serotype introduced in Brazil, during in the 1980s. Since then, this virus has spread in the Brazilian territory, causing several outbreaks. In 2013 the highest number of dengue cases was notified, when compared to the previous years in Brazil, and the state of Goias reported over 160 thousand cases. In this study, we aimed to present the Phylodynamics of DENV-1 isolates from the state of Goias, Brazil, during 2013 outbreak, based on the envelope gene (E) sequences. Phylogenetic analysis revealed that Brazilian DENV-1 isolates are grouped together with viruses from genotype V in two distinct lineages (lineage I and lineage II) reflecting co-circulation. Phylogeographic analyses showed that these lineages were introduced in different moments in Goias, Brazil, using distinct routes, likely originated from the Caribbean. Lineage I was first introduced coming from Rio de Janeiro (2007-2012), followed by the introduction from Argentina (2010-2013). Lineage II was introduced in a single moment from Rio de Janeiro and this clade has existed since 2007-2010. The different viral introduction events demonstrate the viral dispersion process with neighboring regions, which is essential for the maintenance of outbreaks and introduction of new emerging viruses. In conclusion, obtained data reveals the importance of continuous molecular surveillance of this virus in different regions, providing a better understanding of DENV-1 circulation, considering the evolutionary and virus spread patterns. (C) 2016 Elsevier B.V. All rights reserved.
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