期刊
NATURE
卷 603, 期 7902, 页码 679-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41586-022-04411-y
关键词
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资金
- Strategic Health Innovation Partnerships Unit of the South African Medical Research Council
- South African Department of Science and Innovation
- WHO
- National Institutes of Health (NIH) [U01 AI151698]
- Rockefeller Foundation [2021 HTH 017, 2020 HTH 062]
- European Union's Horizon 2020 research and innovation programme, project EpiPose [101003688]
- Wellcome Trust [222574/Z/21/Z, 206298/Z/17/Z, 203135/Z/16/Z, 222754]
- European Research Council [725422]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M010996/1]
- Oxford Martin School
- Rockefeller Foundation
- European Horizon 2020 programme MOOD [874850]
- ANDEMIA G7 Global Health
- South African Medical Research Council
- Department of Science and Innovation
- Wellcome Centre for Infectious Diseases Research in Africa (CIDRI-Africa)
- National Institute for Communicable Diseases of the National Health Laboratory Service
- United States Centers for Disease Control and Prevention [5U01IP001048-05-00]
- African Society of Laboratory Medicine (ASLM)
- Africa Centers for Disease Control and Prevention through Bill and Melinda Gates Foundation [INV-018978]
- UK Foreign, Commonwealth and Development Office and Wellcome [221003/Z/20/Z]
- South African Medical Research Council [SHIPNCD 76756]
- UK Department of Health and Social Care
- Foundation for Innovative New Diagnostics and Fogarty International Center [5D43TW009610]
- NIH [5K24AI131924-04, 5K24AI131928-05]
- Botswana government through the Ministry of Health & Wellness and Presidential COVID-19 Task Force
- Bill & Melinda Gates Foundation [036530]
- Bill and Melinda Gates Foundation [INV-018978] Funding Source: Bill and Melinda Gates Foundation
- European Research Council (ERC) [725422] Funding Source: European Research Council (ERC)
The SARS-CoV-2 epidemic in southern Africa has experienced three distinct waves, driven by different variants. The recently identified Omicron variant has rapidly spread in South Africa and to numerous countries, raising global concern.
Y The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.351) and Delta (B.1.617.2) variants, respectively1-3. In November 2021, genomic surveillance teams in South Africa and Botswana detected a new SARS-CoV-2 variant associated with a rapid resurgence of infections in Gauteng province, South Africa. Within three days of the first genome being uploaded, it was designated a variant of concern (Omicron, B.1.1.529) by the World Health Organization and, within three weeks, had been identified in 87 countries. The Omicron variant is exceptional for carrying over 30 mutations in the spike glycoprotein, which are predicted to influence antibody neutralization and spike function4. Here we describe the genomic profile and early transmission dynamics of Omicron, highlighting the rapid spread in regions with high levels of population immunity.
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