期刊
INFECTION GENETICS AND EVOLUTION
卷 45, 期 -, 页码 250-255出版社
ELSEVIER
DOI: 10.1016/j.meegid.2016.08.034
关键词
Banna virus; Origin; Evolution
资金
- National Natural Science Foundation of China [81290342, 81301479, 81501757]
- Development Grant of the State Key Laboratory of Infectious Disease Prevention and Control [2014SKLID103]
- Natural Science Foundation of Shandong Province, China [ZR2013HQ008]
- young scientist supportive program of Shandong University of Technology
Banna virus (BAV) is an emerging pathogen that causes human viral encephalitis and has been isolated from types of blood-sucking insects and mammals in Asia. However, there are no reported systematic studies that describe the origin and evolution of BAV. Here, a phylogenetic analysis of BAVs isolated from a variety of potential vectors and vertebrate hosts worldwide revealed that BAVs emerged in the beginning of the 20th century and do not exhibit a species barrier. The mean substitution rate of BAVs was 2.467 x 10(-2) substitution/site/year (95% HPD, 1.093 x 10(-3) to 5.628 x 10(-2)). The lineage is mainly composed of BAVs from high-latitude regions, which are the most recently emerged viruses with significantly higher substitution rates compared with the lineage comprised of the isolates from middle or low-latitude regions. The genetic differences between BAV strains are positively correlated with the geographic distribution. Strains from the same latitude regions are almost 100% identical, whereas the differences between strains from long distance regions with different latitudes could be >60%. Our results demonstrate that BAV is an emerging virus at a stage that involves rapid evolution and has great potential for introduction into non-endemic areas. Thus, enhanced surveillance of BAV is highly recommended worldwide. (C) 2016 Elsevier B.V. All rights reserved.
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