期刊
NATURE
卷 599, 期 7885, 页码 471-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41586-021-04082-1
关键词
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资金
- Japan Agency for Medical Research and Development-Core Research for Evolutional Science and Technology [14532135]
- Japan Agency for Medical Research and Development-FORCE [JP21gm4010008]
- RIKEN Aging Project Grant
- Japan Agency for Medical Research and Development-Precursory Research for Innovative Medical Care [JP21gm6110019]
- Japan Society for the Promotion of Science KAKENHI [21K19392]
- Japan Society for the Promotion of Science KAKENHI Grant [18H05411]
- Yanai Fund (Kyoto University)
- RIKEN Special Postdoctoral Researcher (SPDR) Program
- Daiichi Sankyo
- Grants-in-Aid for Scientific Research [21K19392, 18H05411] Funding Source: KAKEN
This study reveals that small metabolites like GABA derived from B-lineage cells can influence immune responses by promoting anti-inflammatory macrophages and enhancing anti-tumour responses. The findings suggest that targeting these metabolites may offer a new approach to immunoregulation.
Small, soluble metabolites not only are essential intermediates in intracellular biochemical processes, but can also influence neighbouring cells when released into the extracellular milieu(1-3). Here we identify the metabolite and neurotransmitter GABA as a candidate signalling molecule synthesized and secreted by activated B cells and plasma cells. We show that B cell-derived GABA promotes monocyte differentiation into anti-inflammatory macrophages that secrete interleukin-10 and inhibit CD8(+) T cell killer function. In mice, B cell deficiency or B cell-specific inactivation of the GABA-generating enzyme GAD67 enhances anti-tumour responses. Our study reveals that, in addition to cytokines and membrane proteins, small metabolites derived from B-lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses.
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