期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 22, 页码 5904-5909出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.2023865
关键词
Netzahualcoyonol; Celastraceae; Salacia multiflora (Lam; ) DC; antibacterial; gram-positive; antibiofilm; synergism
资金
- Fundacao de Amparoa Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Coordenacao de Aperfeicoamento de Pessoal do Nivel Superior (CAPES)
Netzahualcoyonol has bacteriostatic and bactericidal effects against Gram-positive bacteria, disrupts S. aureus biofilm, shows synergistic effects with beta-lactams and aminoglycosides, and has low cytotoxicity, indicating a promising potential as a new effective antibacterial agent.
The expression of virulence factors, such as biofilm formation, in association with the acquisition of resistance to multiple drugs, has evidenced the need for new and effective antimicrobial agents against Staphylococcus aureus. The evaluation of the pharmacological properties of plant-derived compounds is a promising alternative to the development of new antimicrobials. In this study, we aimed to evaluate the antibacterial, antibiofilm, and the synergistic and cytotoxic effects of netzahualcoyonol isolated from Salacia multiflora (Lam.) DC. roots. Netzahualcoyonol presented bacteriostatic (1.56-25.0 mu g/mL) and bactericidal (25.0-400.0 mu g/mL) effects against Gram-positive bacteria, disrupted the biofilm of S. aureus, and presented a synergistic effect after its combination with beta-lactams and aminoglycosides. The low cytotoxicity of netzahualcoyonol (Selectivity Index (SI) for S. aureus (2.56), S. saprophyticus (20.56), and Bacillus subtilis (1.28)) suggests a good security profile. Taken together, these results show that netzahualcoyonol is promising for the development of a new effective antibacterial agent.
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