期刊
INFECTION GENETICS AND EVOLUTION
卷 45, 期 -, 页码 332-340出版社
ELSEVIER
DOI: 10.1016/j.meegid.2016.09.017
关键词
Flavivirus; Evolution; G plus C content
资金
- European Virus Archive goes Global (European Union's Horizon 2020 research and innovation programme) [653316]
- Agence Nationale de la Recherche (RNA Vacci-Code) [ANR-14-CE14-0001]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0001] Funding Source: Agence Nationale de la Recherche (ANR)
Flaviviruses are small RNA viruses that exhibit genetic and ecological diversity and awide range of G + C content (GC%). We discovered that, amongst flaviviruses, the GC% of nucleotides encoding conserved amino acid (AA) residues was consistently higher than that of nucleotides encoding variable AAs. This intriguing phenomenon was also identified for a wide range of other viruses, and some non-viral evolutionary groups. Here, we analyse the possible mechanisms underlying this imbalanced nucleotide content (in particular the role of the specific G content and the AA composition in flaviviral genomes) and discuss its evolutionary implications. Our findings suggest that one of the most simple characteristics of the genetic code (i.e., the G or G + C content of codons) is linked with the evolutionary behavior of the corresponding encoded AAs. (C) 2016 The Authors. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据