Acronyols A and B, new anti-inflammatory prenylated phloroglucinols from the fruits of Acronychia crassipetala

Two new phloroglucinols, acronyols A (1) and B (2) along with the four known (3-6) pholoroglucinols were identified following anti-inflammatory activity guided fractionation from the fruits of Acronychia crassipetala (family Rutaceae). The pholoroglucinols (1-6) were evaluated for their inhibitory effects on NO production and downregulation of TNF-alpha in RAW 264.7 macrophage cell lines. [GRAPHICS] .

Automated summary

Two new phloroglucinols, acronyols A (1) and B (2), along with four known phloroglucinols (3-6) were identified from the fruits of Acronychia crassipetala. These compounds were evaluated for their inhibitory effects on NO production and downregulation of TNF-alpha in RAW 264.7 macrophage cell lines, showing promising anti-inflammatory activities.