α-Glucosidase inhibitory and α-amylase inhibitory activities of compounds isolated from Uvaria rufa Blume

A new C-benzylated flavone, uvariaruflavone (1), along with 13 known compounds (2-14) were isolated from the twig and leaf extracts of Uvaria rufa Blume. Their structures were established by extensive spectroscopic methods. Flavones (5-8) and cyclohexene (10) were isolated from U. rufa for the first time. Most of the isolated compounds were evaluated for their alpha-glucosidase and alpha-amylase inhibitory activities. Of these, uvariaruflavone (1) showed the highest alpha-glucosidase inhibitory activity with an IC50 value of 44.3 mu M, while ferrudiol (12) displayed the highest alpha-amylase inhibitory activity with an IC50 value of 73.5 mu M. [GRAPHICS] .

Automated summary

A new C-benzylated flavone, uvariaruflavone (1), and 13 known compounds (2-14) were isolated from Uvaria rufa Blume. Uvariaruflavone (1) exhibited the highest α-glucosidase inhibitory activity, while ferrudiol (12) showed the highest α-amylase inhibitory activity.