期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 17, 页码 4552-4556出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1993217
关键词
Essential oils; minimum inhibitory concentration; minimum bactericidal concentration; minimum fungicidal concentration; otitis externa; dog
资金
- European Social Fund [LE131-18]
- Hector Puente [FPU17/00466]
- Oscar Mencia-Ares - Spanish Ministry of Education [FPU16/03485]
- Spanish Ministry of Education [BEAGAL-18-106]
- Junta de Castilla y Leon
The study found that cinnamaldehyde exhibited the highest bactericidal and fungicidal activity among the tested compounds against clinical isolates recovered from canine otitis externa cases. Bacterial isolates showed lower susceptibility to essential oils compared to fungal isolates, with a more evident difference for Gram-positive bacteria. No relationship between antibiotic multi-resistant profile and susceptibility to compounds was observed.
Despite the number of studies focused on the potential use of essential oils (EOs) as an alternative to conventional treatments of canine external otitis, there is controversy about their antimicrobial activity which could be explained by differences in technical or biological aspects. This study focuses on the antimicrobial activity of three single EO compounds (thymol, cinnamaldehyde and carvacrol) and two EOs (clove and oregano) against clinical isolates recovered from canine otitis externa cases (14 bacterial isolates belonging to five different genera and six Malassezia pachydermatis isolates). All compounds showed activity and cinnamaldehyde exhibited the highest bactericidal and fungicidal activity. The susceptibility was lower among bacterial isolates than fungal isolates, being this difference more evident for Gram-positive bacteria. No relationship between antibiotic multi-resistant profile and susceptibility to compounds was observed. To sum up, our results provide appropriate information about appropriate concentrations of promising candidates for the topic treatment of canine otitis.
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