期刊
NATURAL PRODUCT RESEARCH
卷 37, 期 7, 页码 1168-1176出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2021.1999943
关键词
Pithecellobium dulce (Roxb.) Benth; gamma-Lactone; flavanols; xanthine oxidase
A newly isolated compound, 3-(hydroxymethyl)-4-(methylamino)-dihydrofuran-2(3H)-one (1), from the leaves of Pithecellobium dulce (Roxb.) Benth., demonstrated promising xanthine oxidase inhibitory activity.
A novel 3-(hydroxymethyl)-4-(methylamino)-dihydrofuran-2(3H)-one (1) was isolated for the first time from the leaves of Pithecellobium dulce (Roxb.) Benth., along with kaempferol (2) and kaempferol-3-rhamnoside (3). It demonstrated a promising xanthine oxidase inhibitory activity with IC50 values of 79.0, 0.38, and 70.4 mu g/mL (allopurinol = 0.4 mu g/mL). This is the first paper to describe the presence of 3-(hydroxymethyl)-4-(methylamino)dihydrofuran-2(3H)-one (1) in the Fabaceae family. The structure elucidation of 3-(hydroxymethyl)-4-(methylamino)dihydrofuran-2(3H)-one (1), kaempferol (2), and kaempferol-3-rhamnoside (3) was determined primarily based on the analyses of MS and NMR results. [GRAPHICS] .
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