Two new lanostane-type triterpenoids from the fungus Periconia sp. TJ403-rc01

The endophytic fungus Periconia sp. TJ403-rc01 (Dematiaceae) isolated from the leaves of Rosa chinensis Jacq. (Rosaceae) was cultivated on rice medium and chemically investigated, affording two new lanostane-type triterpenoids, namely pericinones A and B (1 and 2). Their structures were determined mainly by 1 D and 2 D NMR and HRESIMS data. Notably, it is the first report of lanostane-type triterpenoids from species of Periconia. Compounds 1 and 2 showed moderate anti-inflammatory activity against the NO production with IC50 values of 24.12 +/- 0.73 and 11.38 +/- 1.56 mu M, respectively.

Automated summary

This study reported the chemical investigation of the endophytic fungus Periconia sp. TJ403-rc01 isolated from the leaves of Rosa chinensis Jacq. Two new lanostane-type triterpenoids were discovered and their structures were determined. Notably, these compounds were found for the first time in species of Periconia. Compounds 1 and 2 exhibited moderate anti-inflammatory activity.