期刊
NATURAL PRODUCT REPORTS
卷 39, 期 5, 页码 946-968出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1np00062d
关键词
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资金
- NIH [R01GM121678]
- NSF [CHE-1848076]
- Amgen
- University of California, Irvine
This review discusses the significance of rearranged indole diterpenes of the paxilline type in natural product synthesis up to 2021, highlighting foundational work and new directions in synthesis and research in this field.
Covering: up to 2021 Rearranged indole diterpenes of the paxilline type comprise a large group of fungal metabolites that possess diverse structural features and potentially useful biological effects. The unique indoloterpenoid motif, which is common to all congeners, was first confirmed by crystallographic studies of paxilline. This family of natural products has fascinated organic chemists for the past four decades and has inspired numerous syntheses and synthetic approaches. The present review highlights efforts that have laid the foundation and introduced new directions to this field of natural product synthesis. The introduction includes a summary of biosynthetic considerations and biological activities, the main body of the manuscript provides a detailed discussion of selected syntheses, and the review concludes with a brief outlook on the future of the field.
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