Combination of selol nanocapsules and magnetic hyperthermia hinders breast tumor growth in aged mice after a short-time treatment

Short time treatment with reduced dosages of selol-loaded PLGA nanocapsules (NcSel) combined with magnetic hyperthermia (MHT) is evaluated in aged Erhlich tumor-bearing mice. Clinical, hematological, biochemical, genotoxic and histopathological parameters are assessed during 7 d treatment with NcSel and MHT, separately or combined. The time evolution of the tumor volume is successfully modeled using the logistic mathematical model. The combined therapy comprising NcSel and MHT is able to hinder primary tumor growth and a case of complete tumor remission is recorded. Moreover, no metastasis was diagnosed and the adverse effects are negligible. NcSel plus MHT may represent an effective and safe alternative to cancer control in aged patients. Future clinical trials are encouraged.

Automated summary

The short-term treatment with reduced dosages of NcSel-loaded PLGA nanocapsules combined with magnetic hyperthermia (MHT) was evaluated in aged Erhlich tumor-bearing mice. The study found that the combined therapy was able to inhibit primary tumor growth and achieve complete tumor remission without metastasis and significant adverse effects. This combination may be an effective and safe alternative for cancer control in aged patients.