RNA cancer nanomedicine: nanotechnology-mediated RNA therapy

It has been demonstrated that RNA molecules-mRNA, siRNA, microRNA, and sgRNA-regulate cancer-specific genes, and therefore, RNA-based therapeutics can suppress tumor progression and metastasis by selectively upregulating and silencing these genes. However, the innate defense mechanisms (e.g., exonucleases and RNases) involving the human immune system catalyze the degradation of exogenous RNAs. Thus, nonviral nanoparticles have been employed to deliver therapeutic RNAs for effective cancer gene therapy. In this minireview, we highlight efforts in the past decade to deliver therapeutic RNAs for cancer therapy using novel nanoparticles. Specifically, we review nanoparticles, including lipid, polymer, inorganic, and biomimetic materials, which have been employed to deliver therapeutic RNAs and evoke tumor suppressing responses. Finally, we discuss the challenges and considerations that may accelerate the clinical translation of nanotechnology-mediated RNA therapy.

Automated summary

This article discusses the research progress in using nanoparticles to deliver therapeutic RNAs for cancer therapy. By selectively regulating cancer-specific genes, researchers have successfully suppressed tumor progression and metastasis, overcoming the degradation of exogenous RNAs by the human immune system. Various types of nanoparticles have been developed for delivering therapeutic RNAs and eliciting tumor suppressing responses.