4.8 Article

Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS-NFκB pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Ligand-Dependent Activity Engineering of Glutathione Peroxidase-Mimicking MIL-47(V) Metal-Organic Framework Nanozyme for Therapy

Jiangjiexing Wu et al.

Summary: A ligand engineering strategy was developed to modulate the GPx-mimicking activity of a metal-organic framework (MOF) nanozyme, resulting in the rational regulation of the GPx-mimicking activities of MIL-47(V)-X MOFs. Among them, MIL-47(V)-NH2 demonstrated excellent antioxidation ability, effectively alleviating inflammatory responses in both ear injury and colitis models. This study proves the feasibility of designing high-performance GPx-mimicking nanozymes and highlights the importance of structure-activity relationships in directing in vivo therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Chemistry, Multidisciplinary

A Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells

Namrata Singh et al.

Summary: The study demonstrates that CeVO4 nanozyme can substitute the function of SOD1 and SOD2 in neuronal cells even when the natural enzymes are down-regulated. The nanozyme prevents mitochondrial damage by regulating superoxide levels and restores physiological levels of anti-apoptotic proteins. Additionally, it effectively prevents mitochondrial depolarization and improves cellular ATP levels under oxidative stress.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Engineering, Biomedical

A versatile nanocomposite based on nanoceria for antibacterial enhancement and protection from aPDT-aggravated inflammation via modulation of macrophage polarization

Yue Sun et al.

Summary: In this study, a composite nanomaterial was designed to achieve simultaneous sterilization and inflammation elimination by combining a photosensitizer and ROS scavenger. This nano-based platform can modulate host immunity by down-regulating pro-inflammatory macrophages and up-regulating anti-inflammatory and regenerative macrophages. Additionally, the local ROS level induced by activated inflammation pathway can be adjusted in a very long time due to the charge conversion effect of CeO2, improving the regenerative potential of inflammatory surrounding tissues in the animal model.

BIOMATERIALS (2021)

Article Chemistry, Multidisciplinary

Nanozymes: A clear definition with fuzzy edges

Hui Wei et al.

NANO TODAY (2021)

Article Chemistry, Multidisciplinary

A Phosphatase-Mimetic Nano-Stabilizer of Mast Cells for Long-Term Prevention of Allergic Disease

Peihua Lin et al.

Summary: The ceria nanoparticle-based phosphatase-mimetic nano-stabilizers continuously regulate intracellular phospho-signaling cascades of mast cells to inhibit degranulation of allergic mediators, providing protection against allergic diseases with a long-term therapeutic time window.

ADVANCED SCIENCE (2021)

Article Biochemistry & Molecular Biology

Oxidative Stress Boosts the Uptake of Cerium Oxide Nanoparticles by Changing Brain Endothelium Microvilli Pattern

Roberta Dal Magro et al.

Summary: Vascular oxidative stress exacerbates the progression of Alzheimer's disease, but antioxidant compounds like cerium oxide nanoparticles may help improve vascular function. CNP restored ROS levels and increased uptake in brain cells exposed to A beta, potentially offering protection against neurotoxicity.

ANTIOXIDANTS (2021)

Article Engineering, Biomedical

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Chunxia Ren et al.

Summary: Metformin carbon dots (MCDs) prepared in this study showed excellent biocompatibility and enhanced osteogenic activity more effectively under inflammatory conditions compared to metformin. MCDs also demonstrated promising potential for regenerating lost alveolar bone in periodontitis rat model, indicating a novel nanomaterial for periodontitis treatment with potential pharmacological targets.

ADVANCED HEALTHCARE MATERIALS (2021)

Article Engineering, Biomedical

Rationally integrating peptide-induced targeting and multimodal therapies in a dual-shell theranostic platform for orthotopic metastatic spinal tumors

Yiqun Ma et al.

Summary: A theranostic nanoplatform integrating multiple functions, including excellent targeting ability, dual-drug loading, photothermal therapy, and photoacoustic imaging, efficiently treats metastatic spinal tumors.

BIOMATERIALS (2021)

Article Engineering, Biomedical

A Magnetically Powered Stem Cell-Based Microrobot for Minimally Invasive Stem Cell Delivery via the Intranasal Pathway in a Mouse Brain

Sungwoong Jeon et al.

Summary: Targeted stem cell delivery using magnetically powered microrobots through intranasal administration shows promise in treating central nervous system disorders in a minimally invasive manner.

ADVANCED HEALTHCARE MATERIALS (2021)

Review Materials Science, Biomaterials

Nanozymes go oral: nanocatalytic medicine facilitates dental health

Xiaohang Chen et al.

Summary: Nanozymes, multi-functional nanomaterials with enzyme-like activity, have rapidly gained popularity in biomedicine due to their diverse types and applications. They overcome the limitations of natural enzymes and are paving the way for a new concept in medicine. In the field of dentistry, nanozymes show great potential in treating diseases, monitoring, and tissue regeneration.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

Article Chemistry, Multidisciplinary

An Orally Administered CeO2@Montmorillonite Nanozyme Targets Inflammation for Inflammatory Bowel Disease Therapy

Shengwc. Zhao et al.

ADVANCED FUNCTIONAL MATERIALS (2020)

Review Dentistry, Oral Surgery & Medicine

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Fabio Sa Carneiro Sczepanik et al.

PERIODONTOLOGY 2000 (2020)

Article Medicine, Research & Experimental

Ceria-based nanotheranostic agent for rheumatoid arthritis

Irina Kalashnikova et al.

THERANOSTICS (2020)

Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

Article Multidisciplinary Sciences

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Ping Wang et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Single-atom nanozymes

Liang Huang et al.

SCIENCE ADVANCES (2019)

Review Chemistry, Multidisciplinary

Nanozymes: From New Concepts, Mechanisms, and Standards to Applications

Minmin Liang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

Review Chemistry, Multidisciplinary

Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Jiangjiexing Wu et al.

CHEMICAL SOCIETY REVIEWS (2019)

Review Chemistry, Multidisciplinary

Nanozyme: new horizons for responsive biomedical applications

Dawei Jiang et al.

CHEMICAL SOCIETY REVIEWS (2019)

Review Chemistry, Multidisciplinary

Enzyme Mimicry for Combating Bacteria and Biofilms

Zhaowei Chen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

Article Chemistry, Multidisciplinary

CeO2-x nanorods with intrinsic urease-like activity

K. Korschelt et al.

NANOSCALE (2018)

Article Chemistry, Multidisciplinary

Versatile Dual Photoresponsive System for Precise Control of Chemical Reactions

Can Xu et al.

ACS NANO (2017)

Article Chemistry, Multidisciplinary

Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer's Disease

Hyek Jin Kwon et al.

ACS NANO (2016)

Article Engineering, Biomedical

Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis

Govinda Bhattarai et al.

ACTA BIOMATERIALIA (2016)

Editorial Material Genetics & Heredity

Defining functional signatures of dysbiosis in periodontitis progression

Gary P. Wang

GENOME MEDICINE (2015)

Article Chemistry, Multidisciplinary

Acquired Superoxide-Scavenging Ability of Ceria Nanoparticles

Yuanyuan Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Review Immunology

Periodontitis: from microbial immune subversion to systemic inflammation

George Hajishengallis

NATURE REVIEWS IMMUNOLOGY (2015)

Review Biochemistry & Molecular Biology

Reactive Oxygen Species in Inflammation and Tissue Injury

Manish Mittal et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

Article Developmental Biology

Stem cells and the impact of ROS signaling

Carolina L. Bigarella et al.

DEVELOPMENT (2014)

Article Dentistry, Oral Surgery & Medicine

Composition of Human Peri-implantitis and Periodontitis Lesions

O. Carcuac et al.

JOURNAL OF DENTAL RESEARCH (2014)

Review Materials Science, Multidisciplinary

Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

Can Xu et al.

NPG ASIA MATERIALS (2014)

Article Multidisciplinary Sciences

Prevention of inflammation-mediated bone loss in murine and canine periodontal disease via recruitment of regulatory lymphocytes

Andrew J. Glowacki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Nanoscience & Nanotechnology

Vanadium pentoxide nanoparticles mimic vanadium haloperoxidases and thwart biofilm formation

Filipe Natalio et al.

NATURE NANOTECHNOLOGY (2012)

Review Cell Biology

Crosstalk of reactive oxygen species and NF-kappa B signaling

Michael J. Morgan et al.

CELL RESEARCH (2011)

Article Neurosciences

Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle

Scott K. Powers et al.

JOURNAL OF PHYSIOLOGY-LONDON (2011)

Review Biochemistry & Molecular Biology

Reconciling the chemistry and biology of reactive oxygen species

Christine C. Winterbourn

NATURE CHEMICAL BIOLOGY (2008)

Article Nanoscience & Nanotechnology

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

Lizeng Gao et al.

NATURE NANOTECHNOLOGY (2007)

Article Nanoscience & Nanotechnology

Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides

Junping Chen et al.

NATURE NANOTECHNOLOGY (2006)