期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 39, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2021.102467
关键词
Paclitaxel; 5-Aminolevulinic acid; Magneto nanoplatform; Dual-targeted drug; Chemo-photodynamic synergistic therapy
资金
- National Natural Science Foundation [81772278]
- Fundamental Research Funds for the Central Universities [20720170105]
- Educational and Scientific Research Project for Young and Middle-Aged Teachers of Fujian Province [JT180012]
The designed nanocarriers Tf-5-ALA-PTX-NCs improve drug targeting ability, enabling synergistic chemotherapy and photodynamic therapy, with a controllable drug release switch.
Various drug delivery strategies to improve cancer therapeutic efficacy have been actively investigated. One major challenge is to improve the targeting ability. Here elaborately designed nanocarriers (NCs) named as Tf-5-ALA-PTX-NCs are demonstrated to address this problem. In this nanostructure, paclitaxel (PTX) and 5-aminolevulinic acid (5-ALA) were co-encapsulated within magnetic nanocarriers to achieve synergistic chemotherapy and photodynamic therapy, while transferrin (TI) was conjugated with modified copolymer Pluronic P123 and embedded in the surface of the nanocarriers, which endows nanocarriers with Tf targeting and magnetic targeting to enhance the anti-tumor outcome. Results demonstrated that Tf-5-ALA-PTX-NCs significantly enhanced the targeting drug delivery to MCF-7 cells and synergistically induced apoptosis and death of MCF-7 cells in vitro and highly efficient tumor ablation in vivo. Intriguingly, Tf-5-ALA-PTX-NCs have a controllable on/off' switch to enhance the drug release. The dual-targeted nanocarriers would be a promising versatile antitumor drug delivery and imaging-guided cancer chemo-photodynamic synchronization therapy strategy. (C) 2021 Elsevier Inc. All rights reserved.
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