期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 37, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2021.102417
关键词
Drug delivery; Controlled release; Micelle encapsulation; Hypertension; Amlodipine
资金
- Houston Methodist Research Institute
- NIH-NIGMS [R01GM127558]
Strict adherence to drug administration timing improves efficacy, while poor adherence leads to safety concerns. Nanofluidic technology enables long-acting drug delivery with tunable timing of drug administration.
Hypertension is a chronic condition that requires lifelong therapeutic management. Strict adherence to drug administration timing improves efficacy, while poor adherence leads to safety concerns. In light of these challenges, we present a nanofluidic technology that enables long-acting drug delivery with tunable timing of drug administration using buried gate electrodes in nanochannels. We developed a poly(ethylene glycol) methyl ether-block-poly(e-caprolactone) (PEG-PCL)-based micellar formulation of amlodipine besylate, a calcium channel blocker for hypertension treatment. The electrostatically charged PEG-PCL micellar formulation enhanced drug solubility and rendered amlodipine responsive to electrostatic release gating in nanochannels for sustained release at clinically relevant therapeutic dose. Using a low-power (<3 VDC) gating potential, we demonstrated tunable release of amlodipine-loaded micelles. Additionally, we showed that the released drug maintained biological activity via calcium ion blockade in vitro. This study represents a proof of concept for the potential applicability of our strategy for chronotherapeutic management of hypertension. (C) 2021 Elsevier Inc. All rights reserved.
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