期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 40, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2021.102495
关键词
Bilayered dermal patch; Curcumin nanoparticles; Soluble eggshell membrane; Antibacterial; Antioxidant; Anti-inflammatory
资金
- Wadhwani Research Centre for Bioengineering, IIT Bombay [BT/INF/22/SP23026/2017]
This study developed multifunctional bilayered dermal patches with antibacterial, antioxidant, and anti-inflammatory properties using solvent casting or electrospinning methods. The patches showed improved wound healing compared to the commercial counterpart, with reduced production of reactive oxygen species and inflammatory cytokines and markers, and improved migration of dermal fibroblasts.
In present study, multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed using solvent casting or electrospinning methods and compared for performance. Top layer was made up of polycaprolactone (PCL) and chitosan (CS) while bottom layer was made of polyvinyl alcohol (PVA) with curcumin nanoparticles and soluble eggshell membrane protein (SESM) as the wound healing agents. Curcumin nanoparticles showed reduction in the production of reactive oxygen species (ROS) and inflammatory cytokines and markers in mice T cells or human macrophages, confirming their antioxidant and anti-inflammatory properties while SESM improved migration of human adult dermal fibroblasts, suggesting its contribution to wound healing. The dermal patches were hemocompatible and antibacterial and also provided adequate absorption of wound exudates, support and components required for recruitment of cells and deposition of extracellular matrix to enable superior wound healing than its commercial counterpart in a full thickness excision wound model in rats. (c) 2021 Elsevier Inc. All rights reserved.
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