Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells

Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.

Automated summary

This study successfully developed a new curcumin carrier called SLN-Cs consisting of murumuru butter nanoparticles, and demonstrated that SLN-Cs were more toxic to colon adenocarcinoma cells, indicating that SLN-Cs are suitable carriers of curcumin in aqueous media.