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ADVANCED MATERIALS (2017)
Tumor microenvironment and therapeutic response
Ting Wu et al.
CANCER LETTERS (2017)
HIF-1α/MDR1 pathway confers chemoresistance to cisplatin in bladder cancer
Yi Sun et al.
ONCOLOGY REPORTS (2016)
Efficacy of the nanoparticle-drug conjugate CRLX101 in combination with bevacizumab in metastatic renal cell carcinoma: results of an investigator-initiated phase I-IIa clinical trial
S. M. Keefe et al.
ANNALS OF ONCOLOGY (2016)
Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours
Katarzyna Stepien et al.
MEDICAL ONCOLOGY (2016)
The ever-expanding role of HIF in tumour and stromal biology
Edward L. LaGory et al.
NATURE CELL BIOLOGY (2016)
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer
Caroline Wigerup et al.
PHARMACOLOGY & THERAPEUTICS (2016)
The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V. Liberti et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
Thomas M. Ashton et al.
NATURE COMMUNICATIONS (2016)
The biology and function of fibroblasts in cancer
Raghu Kalluri
NATURE REVIEWS CANCER (2016)
Something in the Air: Hyperoxic Conditioning of the Tumor Microenvironment for Enhanced Immunotherapy
Robert D. Leone et al.
CANCER CELL (2015)
Tumor microenvironment: Sanctuary of the devil
Lanlan Hui et al.
CANCER LETTERS (2015)
Cancer prevention and therapy through the modulation of the tumor microenvironment
Stephanie C. Casey et al.
SEMINARS IN CANCER BIOLOGY (2015)
Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia
Oliver Thews et al.
STRAHLENTHERAPIE UND ONKOLOGIE (2015)
A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis
Shicheng Su et al.
CANCER CELL (2014)
PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation
Muhammad Zaeem Noman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
被撤回的出版物: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (Retracted article. See vol. 119, 2022)
Debangshu Samanta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Hypoxia and tumor-associated macrophages A deadly alliance in support of tumor progression
Eva Van Overmeire et al.
ONCOIMMUNOLOGY (2014)
Hypoxia and the extracellular matrix: drivers of tumour metastasis
Daniele M. Gilkes et al.
NATURE REVIEWS CANCER (2014)
Tumor Cells Upregulate Normoxic HIF-1α in Response to Doxorubicin
Yiting Cao et al.
CANCER RESEARCH (2013)
Reprogramming Metabolism with Metformin Improves Tumor Oxygenation and Radiotherapy Response
Vanessa E. Zannella et al.
CLINICAL CANCER RESEARCH (2013)
Influence of tumour micro-environment heterogeneity on therapeutic response
Melissa R. Junttila et al.
NATURE (2013)
A Hydrogen Peroxide-Responsive O2 Nanogenerator for Ultrasound and Magnetic-Resonance Dual Modality Imaging
Fang Yang et al.
ADVANCED MATERIALS (2012)
Liposome-Encapsulated Hemoglobin Ameliorates Tumor Hypoxia and Enhances Radiation Therapy to Suppress Tumor Growth in Mice
Chieko Murayama et al.
ARTIFICIAL ORGANS (2012)
Arsenic Trioxide Treatment Decreases the Oxygen Consumption Rate of Tumor Cells and Radiosensitizes Solid Tumors
Caroline Diepart et al.
CANCER RESEARCH (2012)
Therapeutic Delivery of siRNA Silencing HIF-1 Alpha with Micellar Nanoparticles Inhibits Hypoxic Tumor Growth
Xi-Qiu Liu et al.
MOLECULAR PHARMACEUTICS (2012)
Hyperbaric oxygen therapy and cancer-a review
Ingrid Moen et al.
TARGETED ONCOLOGY (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis The seed and soil also needs fertilizer
Michael P. Lisanti et al.
CELL CYCLE (2011)
RIBBON-1: Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Chemotherapy With or Without Bevacizumab for First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative, Locally Recurrent or Metastatic Breast Cancer
Nicholas J. Robert et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
NORMALIZATION OF THE VASCULATURE FOR TREATMENT OF CANCER AND OTHER DISEASES
Shom Goel et al.
PHYSIOLOGICAL REVIEWS (2011)
Targeting hypoxia in cancer therapy
William R. Wilson et al.
NATURE REVIEWS CANCER (2011)
Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion
Erika Terzuoli et al.
CANCER RESEARCH (2010)
Hypoxia-induced cell damage is reduced by mild hypothermia and postconditioning with catalase in-vitro: Application of an enzyme based oxygen deficiency system
Karina Zitta et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G. L. Semenza
ONCOGENE (2010)
Hypoxia and Radiation Therapy: Past History, Ongoing Research, and Future Promise
Sara Rockwell et al.
CURRENT MOLECULAR MEDICINE (2009)
Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase
Tomoya Yata et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase
Kenji Hyoudou et al.
JOURNAL OF CONTROLLED RELEASE (2009)
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
KangAe Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Results of the phase III ENRICH (RT-016) study of efaproxiral administered concurrent with whole brain radiation therapy (WBRT) in women with brain Metastases from breast cancer
J. H. Suh et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2008)
Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors
Brian S. Sorg et al.
JOURNAL OF BIOMEDICAL OPTICS (2008)
A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth
Lee M. Greenberger et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Zone-specific remodeling of tumor blood vessels affects tumor growth
Derya Tilki et al.
CANCER (2007)
Glucocorticoids modulate tumor radiation response through a decrease in tumor oxygen consumption
Nathalie Crokart et al.
CLINICAL CANCER RESEARCH (2007)
An experimental study of the use of hyperbaric oxygen to reduce the side effects of radiation treatment for malignant disease
R. A. Williamson
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2007)
Perfluorocarbon-based oxygen delivery
Jean G. Riess
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY (2006)
PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal
Kenji Hyoudou et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Endogenous markers of two separate, hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
MI Koukourakis et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
DH Kong et al.
CANCER RESEARCH (2005)
Tumor radiosensitization by anti inflammatory drugs:: Evidence for a new mechanism involving the oxygen effect
N Crokart et al.
CANCER RESEARCH (2005)
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury
M Thiel et al.
PLOS BIOLOGY (2005)
The prognostic value of the hypoxia markers CA IX and GLUT I and the cytokines VEGF and IL 6 in head and neck squamous cell carcinoma treated by radiotherapy chemotherapy
H De Schutter et al.
BMC CANCER (2005)
Hyperbaric oxygen and radiotherapy
R Mayer et al.
STRAHLENTHERAPIE UND ONKOLOGIE (2005)
PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells
Y Iwai et al.
INTERNATIONAL IMMUNOLOGY (2005)
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
RK Jain
SCIENCE (2005)
Artifical O-2 carriers: Status in 2005
DR Spahn et al.
CURRENT PHARMACEUTICAL DESIGN (2005)
Anemia, tumor hypoxemia, and the cancer patient
J Varlotto et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)
Hyperbaric oxygen alone or combined with 5-FU attenuates growth of DMBA-induced rat mammary tumors
LEB Stuhr et al.
CANCER LETTERS (2004)
Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review
D Pasquier et al.
RADIOTHERAPY AND ONCOLOGY (2004)
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
AL Kung et al.
CANCER CELL (2004)
Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
C Murdoch et al.
BLOOD (2004)
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy:: randomised, double-blind, placebo-controlled trial
M Henke et al.
LANCET (2003)
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
M Yamakawa et al.
CIRCULATION RESEARCH (2003)
Regulation of angiogenesis by hypoxia: role of the HIF system
CW Pugh et al.
NATURE MEDICINE (2003)
Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of metastatic lung tumors in a rat model
PM Petre et al.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2003)
Endogenous markers of tumor hypoxia - Predictors of clinical radiation resistance?
D Vordermark et al.
STRAHLENTHERAPIE UND ONKOLOGIE (2003)
Cyclooxygenase-2 increased the angiogenic and metastatic potential of tumor cells
GP Li et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)
Impact of tumor hypoxia and anemia on radiation therapy outcomes
LB Harrison et al.
ONCOLOGIST (2002)
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
DM Brizel et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
C Koumenis et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Treatment resistance of solid tumors - Role of hypoxia and anemia
P Vaupel et al.
MEDICAL ONCOLOGY (2001)
Combined photodynamic therapy and hyperbaric oxygenation in carcinoma of the esophagus and the esophago-gastric junction
A Maier et al.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2000)
Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
JH Baek et al.
ONCOGENE (2000)
Oxygen regulation of gene expression: A study in opposites
CT D'Angio et al.
MOLECULAR GENETICS AND METABOLISM (2000)
A pathway of neuronal apoptosis induced by hypoxia/reoxygenation:: Roles of nuclear factor-κB and Bcl-2
M Tamatani et al.
JOURNAL OF NEUROCHEMISTRY (2000)
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