4.8 Review

Nanoagent-based theranostic strategies against human coronaviruses

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Review Immunology

Mucosal vaccines - fortifying the frontiers

Ed C. Lavelle et al.

Summary: Mucosal vaccines have the potential to prevent infections and protect against disease development by inducing adaptive immunity at mucosal sites. However, most current mucosal vaccines consist of live attenuated and inactivated whole-cell preparations, and there is a need for safe and effective mucosal adjuvants and innovative antigen discovery and delivery strategies to advance these vaccines. Advancements in understanding innate and adaptive mucosal immunity, including mucosal antigen-presenting cells and resident memory cells, provide valuable insights to inform mucosal adjuvant design for pathogens like SARS-CoV-2 and cancer.

NATURE REVIEWS IMMUNOLOGY (2022)

Article Engineering, Biomedical

Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm

Yun Young Lee et al.

Summary: SARS-CoV-2 infection can lead to cytokine storm and multi-organ failure, but exogenously administered long-acting DNase-1 can effectively reduce cfDNA levels and neutrophil activities, potentially serving as a therapeutic intervention for life-threatening SARS-CoV-2-mediated illnesses.

BIOMATERIALS (2021)

Review Chemistry, Medicinal

Clinical Management of COVID-19: A Review of Pharmacological Treatment Options

Ashli M. Heustess et al.

Summary: Research on pharmacological treatments for COVID-19 has shown mixed data on efficacy and safety, with limited clinical experience with approved and repurposed drugs. The lack of standard treatment makes interpretation of results challenging. Continuous monitoring of the efficacy and safety of current COVID-19 therapeutics is necessary.

PHARMACEUTICALS (2021)

Review Microbiology

Considerations for diagnostic COVID-19 tests

Olivier Vandenberg et al.

Summary: In this review, Vandenberg et al. explore the crucial role of diagnostic tests during the early phase of the COVID-19 pandemic, addressing technical and implementation issues encountered and suggesting future directions for improved diagnostics in potential future outbreaks.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

Article Biophysics

Ultra-sensitive viral glycoprotein detection NanoSystem toward accurate tracing SARS-CoV-2 in biological/non-biological media

Seyyed Alireza Hashemi et al.

Summary: The rapid spread and mutation of viruses have posed serious challenges worldwide. A rapid electrochemical diagnostic kit has been developed to detect pathogenic viruses without the need for extraction or biomarkers, providing accurate identification within approximately 1 minute.

BIOSENSORS & BIOELECTRONICS (2021)

Review Nanoscience & Nanotechnology

Application of Nanotechnology in the COVID-19 Pandemic

Dongki Yang

Summary: COVID-19, caused by SARS-CoV-2, has been a global issue for nearly a year. Development of suitable vaccines and therapeutics, along with the use of intranasal drug delivery and nanotechnology, are promising approaches to combat the pandemic.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Article Chemistry, Physical

Manganese nanodepot augments host immune response against coronavirus

Yizhe Sun et al.

Summary: Interferon (IFN) responses are crucial for host defense against coronavirus and other viruses. A nanodepot of manganese (nanoMn) based on Mn2+ was successfully fabricated using chemical engineering strategy, enhancing cellular uptake and persistent release of Mn2+ in a pH-sensitive manner, thereby strengthening IFN responses and eliciting broad-spectrum antiviral effects.

NANO RESEARCH (2021)

Article Multidisciplinary Sciences

Evolution of antibody immunity to SARS-CoV-2

Christian Gaebler et al.

Summary: After infection with SARS-CoV-2, antibody levels against the spike protein decrease significantly, but the number of memory B cells remain unchanged, indicating an evolving humoral response at 6.2 months after infection.

NATURE (2021)

Article Virology

Inactivation of Human Coronavirus by Titania Nanoparticle Coatings and UVC Radiation: Throwing Light on SARS-CoV-2

Svetlana Khaiboullina et al.

Summary: The global outbreak of COVID-19 caused by SARS-CoV-2 has led to mass vaccinations, but effective disease control strategies and safety precautions remain critical. Photocatalytic self-disinfecting/cleaning surfaces show promise in guiding disinfection policies to control virus spread.

VIRUSES-BASEL (2021)

Article Multidisciplinary Sciences

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

Tiong Kit Tan et al.

Summary: This study introduces a potential vaccine candidate against SARS-CoV-2, utilizing a synthetic virus-like particle platform to present the receptor-binding domain of the virus spike protein. The vaccine induces strong neutralizing antibody responses in mice and pigs, demonstrating thermostability and the potential for global distribution.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Surface Glycan Modification of Cellular Nanosponges to Promote SARS-CoV-2 Inhibition

Xiangzhao Ai et al.

Summary: Increasing surface heparin density on cellular nanosponges can enhance their inhibition against SARS-CoV-2, providing a facile approach to boost antiviral efficacy by mimicking host cells and utilizing glycan engineering strategies.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Chemistry, Physical

Diagnostics for SARS-CoV-2 infections

Bhavesh D. Kevadiya et al.

Summary: The outbreak of SARS-CoV-2 causing COVID-19 has led to diverse and severe symptoms, making accurate diagnosis a key challenge. Rapid diagnosis and treatment measures are crucial in controlling the spread of the virus. The development of diagnostic tools, including nanomaterial-based ones, is essential in the fight against the pandemic.

NATURE MATERIALS (2021)

Article Environmental Sciences

Prospects of nanomaterials-enabled biosensors for COVID-19 detection

Manish Srivastava et al.

Summary: This study provides an overview of the COVID-19 pandemic and nanomaterials-enabled biosensing approaches for the diagnosis of SARS-CoV-2. Despite limited research on nanomaterials-enabled biosensing techniques, the review summarizes nanomaterials-mediated improved biosensing strategies and possible mechanisms for diagnosing COVID-19.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Chemistry, Multidisciplinary

Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection

Cheng Wang et al.

Summary: Membrane nanoparticles derived from ACE2-rich cells were found to effectively block SARS-CoV-2 infection by trapping viral ligands and reducing viral recruitment to host cells. These ACE2-NPs also inhibited viral entry into cells and blocked infection, providing a promising avenue for COVID-19 treatment.

ACS NANO (2021)

News Item Multidisciplinary Sciences

STOCKING THE SHELVES FOR THE NEXT PANDEMIC

Elie Dolgin

NATURE (2021)

Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

Review Pediatrics

Biomarkers in COVID-19: An Up-To-Date Review

Madhusudan Samprathi et al.

Summary: Biomarkers play a crucial role in the COVID-19 pandemic, providing important information for clinical diagnosis and treatment. Different categories of biomarkers offer valuable insights, but there is still a lack of definitive answers on which biomarkers to evaluate when and in whom, and how best to utilize this information.

FRONTIERS IN PEDIATRICS (2021)

Article Chemistry, Analytical

Voltammetric-based immunosensor for the detection of SARS-CoV-2 nucleocapsid antigen

Shimaa Eissa et al.

Summary: A label-free square wave voltammetry-based biosensing platform for detecting SARS-CoV-2 in nasopharyngeal samples was developed with high sensitivity and selectivity. The biosensor demonstrated successful detection of the SARS-CoV-2 virus in clinical samples, showing a good correlation with RT-PCR cycle threshold values.

MICROCHIMICA ACTA (2021)

Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

Letter Biochemistry & Molecular Biology

SARS-CoV-2 variants of concern are emerging in India

Jasdeep Singh et al.

NATURE MEDICINE (2021)

Article Nanoscience & Nanotechnology

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19

Zhenhua Li et al.

Summary: The authors demonstrate that nanovesicles coated with lung spheroid cell membranes expressing angiotensin-converting enzyme 2 can bind and neutralize SARS-CoV-2, potentially serving as a therapeutic agent for treating COVID-19.

NATURE NANOTECHNOLOGY (2021)

Review Nanoscience & Nanotechnology

Environmental dimensions of the protein corona

Korin E. Wheeler et al.

Summary: This review discusses the importance of dynamic protein corona composition in mediating the fate of nanomaterials in the environment, as well as future steps in eco-corona studies. The formation of the biomolecular coating on nanomaterials entering the environment, known as the eco-corona, is still an emerging area of research. Proteins within the eco-corona play a crucial role in defining the biological identity of nanomaterials and their impacts on the environment.

NATURE NANOTECHNOLOGY (2021)

Review Genetics & Heredity

The biological and clinical significance of emerging SARS-CoV-2 variants

Kaiming Tao et al.

Summary: The emergence of multiple SARS-CoV-2 variants has significant impacts on the epidemiological and clinical aspects of the COVID-19 pandemic, including increased virus transmission rates, heightened risk of reinfection, and reduced effectiveness of neutralizing antibodies and vaccines. These variants have introduced new challenges to COVID-19 research, necessitating additional avenues of laboratory, epidemiological, and clinical studies.

NATURE REVIEWS GENETICS (2021)

Article Multidisciplinary Sciences

Inhalable nanocatchers for SARS-CoV-2 inhibition

Han Zhang et al.

Summary: Amid the global COVID-19 pandemic caused by SARS-CoV2, scientists have developed a novel approach to combat the virus, by designing hACE2-containing nanocatchers to protect cells from infection and potentially provide an alternative treatment option. This innovative method shows promising results in inhibiting SARS-CoV-2 infections, including mutated strains, and offers great potential for future clinical use in the ongoing epidemic.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2

Xingyue An et al.

Summary: The development of an intranasal subunit vaccine that induces mucosal immunity in the respiratory tract has been reported, demonstrating the potential to prevent infection establishment in individuals and disease transmission.

ISCIENCE (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Petra Mlcochova et al.

Summary: The B.1.617.2 (Delta) variant of SARS-CoV-2 has lower sensitivity to antibodies and higher replication efficiency compared to other lineages, which may contribute to its dominance and reduced vaccine effectiveness, highlighting the need for continued infection control measures post-vaccination.

NATURE (2021)

Article Biochemistry & Molecular Biology

Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines

Weilin Zhou et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Letter Biochemistry & Molecular Biology

The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

Cheng Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

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A novel coronavirus outbreak of global health concern

Chen Wang et al.

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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

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Real-time RT-PCR in COVID-19 detection: issues affecting the results

Alireza Tahamtan et al.

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Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period

Stephen M. Kissler et al.

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COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

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Roman Woelfel et al.

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Kristian G. Andersen et al.

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Quan-Xin Long et al.

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Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

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Giacomo Reina et al.

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Na-Na Zhang et al.

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Muhammad Adnan Shereen et al.

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Cristiano Conte et al.

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Chunxi Zeng et al.

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Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant

Sha Peng et al.

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Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

Qiangzhe Zhang et al.

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Sepehr Talebian et al.

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Helena F. Florindo et al.

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A molecular docking study repurposes FDA approved iron oxide nanoparticles to treat and control COVID-19 infection

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COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

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Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines

Lang Rao et al.

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Christian Jean Michel et al.

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Zhongmin Tang et al.

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Bapurao Surnar et al.

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Sundararaj S. Jeremiah et al.

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Riddhiman Medhi et al.

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Shlok Jindal et al.

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Bin Chen et al.

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