期刊
NANO LETTERS
卷 21, 期 20, 页码 8723-8733出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c02899
关键词
psoriasis; gold nanoparticles; alkyl group; skin-nano interaction; topical delivery
类别
资金
- Research Grants Council (RGC) [14300718]
- Chow Yuk Ho Technology Centre for Innovative Medicine
- ViceChancellor Discretionary Fund at CUHK
- Croucher Innovation Award from the Croucher Foundation
The study introduces a self-therapeutic nanoparticle for the prevention and treatment of psoriasis. Results show that the nanoparticles can effectively penetrate the stratum corneum to inhibit psoriasis development and treat established psoriasis.
We present a self-therapeutic nanoparticle for topical delivery to epidermal keratinocytes to prevent and treat psoriasis. Devoid of known chemical or biological antipsoriatic drugs, this sub-15 nm nanoparticle contains a 3 nm gold core and a shell of 1000 Da polyethylene glycol strands modified with 30% octadecyl chains. When it is applied to imiquimod-induced psoriasis mice without an excipient, the nanoparticle can cross the stratum corneum and preferentially enter keratinocytes. Applying the nanoparticles concurrently with imiquimod prevents psoriasis and downregulates genes that are enriched in the downstream of the interleukin-17 signaling pathway and linked to epidermis hyperproliferation and inflammation. Applying the nanoparticles after psoriasis is established treats the psoriatic skin as effectively as standard steroid and vitamin D analog-based therapy but without hair loss and skin wrinkling. The nanoparticles do not accumulate in major organs or induce long-term toxicity. Our nanoparticle offers a simple, safe, and effective alternative for treating psoriasis.
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