期刊
NANO LETTERS
卷 21, 期 20, 页码 8785-8793出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c03070
关键词
surface-enhanced Raman spectroscopy; SERS; nanocomposite scaffold; 3D cell culture; drug diffusion
类别
资金
- Spanish Ministry of Science, Innovation and Universities
- European Research Council [787510, 819242]
- Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency [MDM-2017-0720]
- MICINN [PID2019-108787RB-I00]
- European Research Council (ERC) [787510, 819242] Funding Source: European Research Council (ERC)
This study presents a 3D cancer model incorporating a hydrogel-based scaffold with gold nanorods, in addition to printed nanocomposite inks that can support cell growth and reveal drug diffusion properties, paving the way for novel strategies in cancer therapy drug discovery.
Monitoring dynamic processes in complex cellular environments requires the integration of uniformly distributed detectors within such three-dimensional (3D) networks, to an extent that the sensor could provide real-time information on nearby perturbations in a non-invasive manner. In this context, the development of 3D-printed structures that can function as both sensors and cell culture platforms emerges as a promising strategy, not only for mimicking a specific cell niche but also toward identifying its characteristic physicochemical conditions, such as concentration gradients. We present herein a 3D cancer model that incorporates a hydrogel-based scaffold containing gold nanorods. In addition to sustaining cell growth, the printed nanocomposite inks display the ability to uncover drug diffusion profiles by surface-enhanced Raman scattering, with high spatiotemporal resolution. We additionally demonstrate that the acquired information could pave the way to designing novel strategies for drug discovery in cancer therapy, through correlation of drug diffusion with cell death.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据