期刊
NANO LETTERS
卷 22, 期 1, 页码 211-219出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c03514
关键词
malaria; experimental cerebral malaria; cell-membrane coating; dihydroartemisinin; nanodrug
类别
资金
- Excellent Young Scientists Fund [22022407]
- National Natural Science Foundation of China [21874008, 22004006, 81802046]
- Major Program of National Natural Science Foundation of China [21890740, 21890742]
- Special Foundation for State Major Research Program of China [2019YFC1606603]
- SZU Top Ranking Project [860000002100165]
- Beijing Municipa Science and Technology Commission [z131102002813058]
- Principle Investigator Program of Hubei University of Medicine [HBMUPI202101]
- Stability Support Plan of Shenzhen University [8940206/0200]
This study introduces a nanoparticle formulation of an antimalarial drug coated in a biomimetic membrane derived from brain microvascular endothelial cells and demonstrates its therapeutic efficacy in a mouse model of cerebral malaria, offering new insight into nanoparticle-based therapeutics for malaria and parasitic infections.
Human malaria is a global life-threatening infectious disease. Cerebral malaria (CM) induced by Plasmodium falciparum parasites accounts for 90% of malaria deaths. Treating CM is challenging due to inadequate treatment options and the development of drug resistance. We describe a nanoparticle formulation of the antimalarial drug dihydroartemisinin that is coated in a biomimetic membrane derived from brain microvascular endothelial cells (BMECs) and test its therapeutic efficacy in a mouse model of experimental cerebral malaria (ECM). The membrane-coated nanoparticle drug has a prolonged drug-release profile and enhanced dual targeting killing efficacy toward parasites residing in red blood cells (iRBCs) and iRBCs obstructed in the BMECs (for both rodent and human). In a mice ECM model, the nanodrug protects the brain, liver, and spleen from infection-induced damage and improves the survival rate of mice. This so-called nanodrug offers new insight into engineering nanoparticle-based therapeutics for malaria and other parasitic pathogen infections.
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