期刊
NANO LETTERS
卷 22, 期 4, 页码 1759-1768出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.1c05003
关键词
Severe acute pancreatitis; Tetrahedral framework nucleic acids; Multiorgan injury; Apoptosis; Inflammation
类别
资金
- National Key R&D Program of China [2019YFA0110600]
- National Natural Science Foundation of China [81970916, 81671031]
- Open Research Program of National Facility for Translational Medicine (Shanghai) [TMSK-2021-204]
The use of tetrahedral framework nucleic acids (tFNAs) in treating severe acute pancreatitis (SAP) in mice has proven effective in suppressing inflammation and preventing pathological cell death.
Severe acute pancreatitis (SAP) is an inflammatory disease of the pancreas accompanied by tissue injury and necrosis. It not only affects the pancreas but also triggers a systemic inflammatory response that leads to multiorgan failure or even death. Moreover, there is no effective treatment currently that can reverse the disease progression. In this study, tetrahedral framework nucleic acids (tFNAs) were utilized to treat SAP in mice for the first time and proved to be effective in suppressing inflammation and preventing pathological cell death. Serum levels of pancreatitis-related biomarkers witnessed significant changes after tFNAs treatment. Reduction in the expression of certain cytokines involved in local and systemic inflammatory response were observed, together with alteration in proteins related to cell death and apoptosis. Collectively, our results demonstrate that tFNAs could both alleviate SAP and its subsequent multiorgan injury in mice, thus offering a novel and effective option to deal with SAP in the future.
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