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Laryngospasm: A frequently underrecognized symptom in amyotrophic lateral sclerosis

MUSCLE & NERVE (2022)

Laryngospasm in amyotrophic lateral sclerosis

Ryan D. Gotesman et al.

Summary: Laryngospasm is an underreported symptom in ALS, with a prevalence of 4% in this study. It often occurs in patients with moderate bulbar dysfunction, independent of respiratory function. Triggers include excessive saliva irritating the vocal cords and eating a meal. Further research is needed to understand the pathophysiology and optimal treatment strategies for laryngospasm in ALS patients.

MUSCLE & NERVE (2022)

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Article Clinical Neurology

Case Report: Laryngospasm as Initial Manifestation of Amyotrophic Lateral Sclerosis in a Long-Survival Patient With Heterozygous p.D90A-SOD1 Mutation

Giuliana Capece et al.

Summary: ALS is a fatal neurodegenerative disease that affects motor neurons, with the SOD1 gene playing a significant role in its pathogenesis. The p.D90A mutation in the SOD1 gene is the most common worldwide, showing both autosomal and recessive inheritance in different populations. Genetic analysis can assist in diagnosing ALS, particularly in patients with insidious onset symptoms.

FRONTIERS IN NEUROLOGY (2021)

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Article Clinical Neurology