期刊
MOVEMENT DISORDERS
卷 37, 期 1, 页码 196-200出版社
WILEY
DOI: 10.1002/mds.28805
关键词
apolipoprotein E; Parkinson's disease; motor progression; alpha-synuclein; amyloid beta
资金
- National Natural Science Foundation of China [81771216]
- Key Research and Development Program of Zhejiang Province [2020C03020]
- Natural Science Foundation of Zhejiang Provincial [LY18H090003]
- Michael J. Fox Foundation for Parkinson's Research
- AbbVie
- Avid
- Bristol-Myers Squibb
- Covance
- GE Healthcare
- Genentech
- GlaxoSmithKline
- Lundbeck
- Meso Scale Discovery
- Pfizer
- Piramal
- Roche
- Servier
- Teva
- UCB
- Lilly
- Biogen
- Merck
The study indicates that patients with Parkinson's disease who carry the APOE ε4 allele may experience faster motor progression, especially in those with high amyloid beta burden. This suggests a potential link between APOE ε4 and rapid motor decline in PD.
Background Emerging evidence indicates that the apolipoprotein E (APOE) epsilon 4 exacerbates alpha-synuclein pathology. Objective To determine whether APOE epsilon 4 contributes to motor progression in early Parkinson's disease (PD). Methods Longitudinal data were obtained from 384 patients with PD divided into APOE epsilon 4 carriers (n = 85) and noncarriers (n = 299) in the Parkinson's Progression Marker Initiative. Participants underwent yearly motor assessments over a mean follow-up period of 78.9 months. Repeated measures and linear mixed models were used to test the effects of APOE epsilon 4. Results The motor progression was significantly more rapid in patients with PD carrying APOE epsilon 4 than in noncarriers (beta = 0.283, P = 0.026, 95% confidence interval: 0.033-0.532). Through subgroup analysis, we found that the effect of APOE epsilon 4 was significant only in patients with high amyloid beta burden (beta = 0.761, P < 0.001, 95% confidence interval: 0.0356-1.167). Conclusions APOE epsilon 4 may be associated with rapid motor progression in PD. (c) 2021 International Parkinson and Movement Disorder Society
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