4.6 Article

Neuroinflammation in the Cerebellum and Brainstem in Friedreich Ataxia: An [18F]-FEMPA PET Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

[11C]PBR28 MR-PET imaging reveals lower regional brain expression of translocator protein (TSPO) in young adult males with autism spectrum disorder

N. R. Zurcher et al.

Summary: Lower regional TSPO expression in individuals with ASD compared to controls suggests abnormalities in neuroimmune processes or mitochondrial dysfunction. The stability and replicability of TSPO expression over time in ASD individuals were confirmed by voxelwise analysis.

MOLECULAR PSYCHIATRY (2021)

Article Clinical Neurology

Longitudinal structural brain changes in Friedreich ataxia depend on disease severity: the IMAGE-FRDA study

Louisa P. Selvadurai et al.

Summary: This study found evidence of earlier cerebellar and later cerebral degeneration in Friedreich ataxia progression, with individuals showing greater white matter volume loss in specific regions, depending on their severity of symptoms and age of disease onset. Additionally, changes in cerebral atrophy and axial diffusivity were observed in individuals with more severe symptoms, while progression in radial diffusivity was more pronounced in those with earlier disease onset.

JOURNAL OF NEUROLOGY (2021)

Article Clinical Neurology

[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease

Jelle van den Ameele et al.

Summary: The study suggests that using TSPO radioligands in brain PET-MRI may be valuable for detecting mitochondrial diseases, with differences in radiotracer binding among patients with different types of mitochondrial gene mutations, correlating with clinical presentations.

NEUROLOGY (2021)

Article Clinical Neurology

Brain Structure and Degeneration Staging in Friedreich Ataxia: Magnetic Resonance Imaging Volumetrics from the ENIGMA-Ataxia Working Group

Ian H. Harding et al.

Summary: Friedreich ataxia (FRDA) is characterized by progressive movement incoordination and is associated with significant reductions in brain volume in regions such as the brainstem and cerebellum. Differences in brain volume are influenced by factors such as age of onset, disease duration, and severity, with certain regions showing more pronounced volume deficits in more advanced cases. This study highlights the importance of considering the spatial profile and progressive evolution of structural brain abnormalities in individuals with FRDA for further research and clinical trials.

ANNALS OF NEUROLOGY (2021)

Review Biotechnology & Applied Microbiology

Central Nervous System Therapeutic Targets in Friedreich Ataxia

Ian H. Harding et al.

HUMAN GENE THERAPY (2020)

Review Biochemistry & Molecular Biology

Recent Developments in TSPO PET Imaging as A Biomarker of Neuroinflammation in Neurodegenerative Disorders

Eryn L. Werry et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Editorial Material Clinical Neurology

Neuroinflammation - a common thread in neurological disorders

Nils Erik Gilhus et al.

NATURE REVIEWS NEUROLOGY (2019)

Article Clinical Neurology

Longitudinal evaluation of iron concentration and atrophy in the dentate nuclei in friedreich ataxia

Phillip G. D. Ward et al.

MOVEMENT DISORDERS (2019)

Review Endocrinology & Metabolism

Sifting through the surfeit of neuroinflammation tracers

Paul Cumming et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

Article Biochemistry & Molecular Biology

Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia

T. Notter et al.

MOLECULAR PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI

Cristina Lois et al.

ACS CHEMICAL NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients

Daniel Nachun et al.

HUMAN MOLECULAR GENETICS (2018)

Review Behavioral Sciences

Cerebral abnormalities in Friedreich ataxia: A review

Louisa P. Selvadurai et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2018)

Article Biochemistry & Molecular Biology

Frataxin deficiency impairs mitochondrial biogenesis in cells, mice and humans

Mittal J. Jasoliya et al.

HUMAN MOLECULAR GENETICS (2017)

Review Biochemistry & Molecular Biology

In Vivo Imaging of Human Neuroinflammation

Daniel S. Albrecht et al.

ACS CHEMICAL NEUROSCIENCE (2016)

Review Biochemistry & Molecular Biology

The role of interleukin-6 signaling in nervous tissue

Michelle Rothaug et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Neurosciences

A probabilistic atlas of the cerebellar white matter

K. M. van Baarsen et al.

NEUROIMAGE (2016)

Article Neurosciences

Dorsal root ganglia in Friedreich ataxia: satellite cell proliferation and inflammation

Arnulf H. Koeppen et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer's disease patients and control subjects

Andrea Varrone et al.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2015)

Article Biochemistry & Molecular Biology

Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia

Genki Hayashi et al.

HUMAN MOLECULAR GENETICS (2014)

Review Clinical Neurology

Friedreich Ataxia: Neuropathology Revised

Arnulf H. Koeppen et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Clinical Neurology

Clinical Features of Friedreich Ataxia

Martin B. Delatycki et al.

JOURNAL OF CHILD NEUROLOGY (2012)

Review Neurosciences

FreeSurfer

Bruce Fischl

NEUROIMAGE (2012)

Article Biochemistry & Molecular Biology

Frataxin deficiency induces Schwann cell inflammation and death

Chunye Lu et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Clinical Neurology

The pathogenesis of Friedreich ataxia and the structure and function of frataxin

Massimo Pandolfo et al.

JOURNAL OF NEUROLOGY (2009)

Review Neurosciences

Does neuroinflammation fan the flame in neurodegenerative diseases?

Tamy C. Frank-Cannon et al.

MOLECULAR NEURODEGENERATION (2009)

Article Neurosciences

A probabilistic MR atlas of the human cerebellum

Joern Diedrichsen et al.

NEUROIMAGE (2009)