期刊
MOLECULES
卷 27, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/molecules27041416
关键词
cysteine-related thiolome; cysteine transporters; hypoxia; hypertension; kidney metabolism; glutathione; H2S; bioenergetics; ferroptosis; lysosomes
资金
- Fundacao para Ciencia e Tecnologia [PTDC/MED-TOX/30418/2017]
- iNOVA4Health [UID/Multi/04462/2013]
- FCT [SFRH/BD/131331/2017, PD/BD/135484/2018]
- Fundação para a Ciência e a Tecnologia [PTDC/MED-TOX/30418/2017, PD/BD/135484/2018, SFRH/BD/131331/2017] Funding Source: FCT
This review presents in vivo evidence showing that the kidney is rich in cysteine compared to the liver or brain. The study highlights the various forms and importance of cysteine in renal metabolism, providing insights into kidney function, blood pressure regulation, and potential clinical applications in precision medicine.
In this review encouraged by original data, we first provided in vivo evidence that the kidney, comparative to the liver or brain, is an organ particularly rich in cysteine. In the kidney, the total availability of cysteine was higher in cortex tissue than in the medulla and distributed in free reduced, free oxidized and protein-bound fractions (in descending order). Next, we provided a comprehensive integrated review on the evidence that supports the reliance on cysteine of the kidney beyond cysteine antioxidant properties, highlighting the relevance of cysteine and its renal metabolism in the control of cysteine excess in the body as a pivotal source of metabolites to kidney biomass and bioenergetics and a promoter of adaptive responses to stressors. This view might translate into novel perspectives on the mechanisms of kidney function and blood pressure regulation and on clinical implications of the cysteine-related thiolome as a tool in precision medicine.
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