期刊
MOLECULES
卷 26, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/molecules26226932
关键词
soft corals; 5-epi-sinuleptolide; pancreatic cancer; cytotoxicity; STAT3
资金
- Ministry of Science and Technology of Taiwan [MOST 107-2320-B-110-001-MY3, MOST 109-2320-B-037-029]
- NSYSU-KMU Joint Research Project [MOST 109-2320-B-037-029, NSYSUKMU 109-I005]
- Kaohsiung Medical University Research Foundation [KMU-M109009]
- [KMU-TC109A01-1]
- [110-I004]
This study demonstrates that 5-epi-Sinuleptolide exhibits anti-pancreatic cancer potential by inhibiting cell proliferation, inducing apoptosis, and suppressing invasion. The mechanism involves the inhibition of JAK2/STAT3, AKT, and ERK phosphorylation. This suggests a new therapeutic approach for pancreatic cancer treatment.
Pancreatic ductal adenocarcinoma is one of the most lethal malignancies: more than half of patients are diagnosed with a metastatic disease, which is associated with a five-year survival rate of only 3%. 5-epi-Sinuleptolide, a norditerpene isolated from Sinularia sp., has been demonstrated to possess cytotoxic activity against cancer cells. However, the cytotoxicity against pancreatic cancer cells and the related mechanisms are unknown. The aim of this study was to evaluate the anti-pancreatic cancer potential of 5-epi-sinuleptolide and to elucidate the underlying mechanisms. The inhibitory effects of 5-epi-sinuleptolide treatment on the proliferation of pancreatic cancer cells were determined and the results showed that 5-epi-sinuleptolide treatment inhibited cell proliferation, induced apoptosis and G2/M cell cycle arrest, and suppressed the invasion of pancreatic cancer cells. The results of western blotting further revealed that 5-epi-sinuleptolide could inhibit JAK2/STAT3, AKT, and ERK phosphorylation, which may account for the diverse cytotoxic effects of 5-epi-sinuleptolide. Taken together, our present investigation unveils a new therapeutic and anti-metastatic potential of 5-epi-sinuleptolide for pancreatic cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据