4.6 Review

Advances of Microneedles in Biomedical Applications

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Article Instruments & Instrumentation

Topical delivery of 5-fluorouracil-loaded carboxymethyl chitosan nanoparticles using microneedles for keloid treatment

Juhyun Park et al.

Summary: Keloids are skin conditions induced by injuries, and a study has suggested a promising treatment method using microneedles to deliver 5-fluorouracil (5-FU) loaded carboxymethyl chitosan (CMC) nanoparticles directly into keloid fibroblasts. This delivery system not only inhibits the fibroblasts effectively but also has the feasibility of self-administration without pain, showing potential for treating keloid scars.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

Article Chemistry, Multidisciplinary

Limpet Tooth-Inspired Painless Microneedles Fabricated by Magnetic Field-Assisted 3D Printing

Xiangjia Li et al.

Summary: Microneedle arrays offer advantages in drug delivery, and 3D printing can overcome manufacturing challenges, though limitations on material and printing capability remain. Limpet teeth structures inspire mechanically reinforced biomedical microneedles. A bioinspired painless microneedle array is fabricated using magnetic field-assisted 3D printing for long-term drug delivery suitability.

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Effective Photothermal Therapy Mediated by Indocyanine Green Nanoparticle Tip-Loaded Microneedles to Enhance Checkpoint Inhibitor Immunotherapy for Melanoma Treatment

Peipei Yang et al.

Summary: A novel microneedle design utilizing nanotechnology and centrifugal force was developed to effectively load indocyanine green (ICG), resulting in higher drug loading amount and distribution at the microneedle tips, leading to better in vivo photothermal performance. This microneedle system, composed of clinically approved components, demonstrated a synergetic effect when combined with a checkpoint inhibitor-loaded core-shell microneedle system, showing promise for enhancing checkpoint inhibitor immunotherapy in clinical translation.

ACS APPLIED NANO MATERIALS (2021)

Article Chemistry, Multidisciplinary

Silk fibroin microneedles fabricated by digital light processing 3D printing

Donghyeok Shin et al.

Summary: This report introduces a method for one-step 3D structuring of protein-based microneedles using digital light processing (DLP) 3D printing. By using riboflavin as a photoinitiator, the printing of silk fibroin (SF) microneedles and the delivery of molecules to the skin in biomedical applications are achieved successfully.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Hydrogel-Forming Microneedles: Current Advancements and Future Trends

Joseph G. Turner et al.

Summary: Hydrogel-forming microneedles offer enhanced transdermal drug delivery effectiveness and potential for passive extraction of interstitial fluid from the skin, making them suitable for biocompatible minimally invasive monitoring devices.

MACROMOLECULAR BIOSCIENCE (2021)

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A microneedle platform for buccal macromolecule delivery

Ester Caffarel-Salvador et al.

Summary: A highly drug-loaded microneedle patch was developed for rapid delivery of human insulin and growth hormone to the buccal cavity of swine, with the hard palate identified as the preferred application site. This study suggests that microneedle patches could increase medication adherence and provide painless delivery for pediatric and elderly populations.

SCIENCE ADVANCES (2021)

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3D-printed microneedles in biomedical applications

Sajjad Rahmani Dabbagh et al.

Summary: Nano-/micro-fabricated microneedles fabricated by 3D printing methods offer customization, cost-efficiency, rapid design iterations, and enhanced accessibility, enabling applications in biomedical devices and healthcare technologies. The development of 3D-printed microneedles has revolutionized pain-free controlled release drug delivery systems, fluid extraction devices, biosignal acquisition, and point-of-care diagnostic devices for personalized medicine.

ISCIENCE (2021)

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Synthesis and characterization of PVP microneedle patch using metal bioelectrodes for novel drug delivery system

Su-Jin Yang et al.

Summary: This study developed a novel microneedle patch using metal bioelectrodes for enhanced drug delivery efficiency and biocompatibility. The metal-coated PVP microneedle patches show significant improvements in drug release efficiency and mechanical properties, making them suitable for cosmetic and medical applications.

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Determination of the mechanical properties of polymeric microneedles by micromanipulation

Guangsheng Du et al.

Summary: This study used micromanipulation technique to determine the mechanical strength of two types of hyaluronic acid microneedles, one loaded with model drugs and the other without. The data obtained suggest that the molecular weight of the polymer and the loading of drug into the microneedles significantly affect the rupture behavior and mechanical properties of the microneedles, providing a foundation for preparing sufficiently strong microneedles for controlled drug delivery.

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Zn-MOF Encapsulated Antibacterial and Degradable Microneedles Array for Promoting Wound Healing

Shun Yao et al.

Summary: A degradable zinc-MOF encapsulated microneedles array was fabricated in this study, showing excellent antibacterial activity and biocompatibility, which can accelerate wound healing and tissue regeneration.

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Insights into the mechanics of solid conical microneedle array insertion into skin using the finite element method

Wenting Shu et al.

Summary: This study develops a finite element model for simulating microneedle insertion and penetration into human skin, emphasizing the importance of accurate computational modeling in understanding the mechanics of microneedle insertion. The study reveals the effects of skin pretension and microneedle array geometry on microneedle penetration efficiency.

ACTA BIOMATERIALIA (2021)

Review Pharmacology & Pharmacy

The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

Emma McAlister et al.

Summary: Diabetes affects 450 million adults worldwide, with chronic hyperglycaemia potentially leading to fibrosis; Microneedle arrays offer a promising alternative for transdermal drug delivery; The potential of microneedle technology in revolutionizing diabetes management is significant.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Microarray patches: Breaking down the barriers to contraceptive care and HIV prevention for women across the globe

Alejandro J. Paredes et al.

Summary: Microarray patches (MAPs) are a novel platform for delivering hormonal contraception and antiretroviral drugs, providing enhanced drug delivery to the systemic circulation. These minimally invasive patches can be self-administered by users, reducing the burden on healthcare personnel and eliminating the risk of needle-stick injuries.

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3D printed hollow microneedles array using stereolithography for efficient transdermal delivery of rifampicin

Vivek Yadav et al.

Summary: A 3D printed assembly of hollow microneedles, designed and manufactured using stereolithography technology, was used for transdermal delivery of high molecular weight antibiotics. The microneedles were designed with sub-apical holes for improved mechanical strength, and were characterized for quality and uniformity. Ex vivo and in vivo experiments confirmed the efficient penetration and desired bioavailability of the antibiotic.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Materials Science, Multidisciplinary

Biodegradable Porous Microneedles for an Electric Skin Patch

Hiroya Abe et al.

Summary: An array of porous microneedles made of PLGA was fabricated with a porosity around 50% through a combination of molding and freeze-drying methods. The mechanical strength of the PLGA microneedles was enhanced by modification with CMC, resulting in decreased transdermal resistance, thus improving efficiency and safety of DC current-based transdermal techniques.

MACROMOLECULAR MATERIALS AND ENGINEERING (2021)

Article Chemistry, Multidisciplinary

Dissolving undercut microneedle arrays for multicomponent cutaneous vaccination

Stephen C. Balmert et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Non-transdermal microneedles for advanced drug delivery

KangJu Lee et al.

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Microneedles for transdermal diagnostics: Recent advances and new horizons

Gui-Shi Liu et al.

BIOMATERIALS (2020)

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3D printed microneedles for anticancer therapy of skin tumours

Md Jasim Uddin et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Jicheng Yu et al.

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Microneedle ocular patch: fabrication, characterization, andex-vivoevaluation using pilocarpine as model drug

Girdhari Roy et al.

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Optimal scaling analysis of polymeric microneedle length and its effect on transdermal insulin delivery

Shoukai Chen et al.

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A Double-Layered Microneedle Platform Fabricated through Frozen Spray-Coating

Ning Xiaoyu et al.

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Combined Silk Fibroin Microneedles for Insulin Delivery

Mingmei Zhu et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Advances in Antimicrobial Microneedle Patches for Combating Infections

Rezvan Jamaledin et al.

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Article Pharmacology & Pharmacy

Fabrication, characterization and comparison of α-arbutin loaded dissolving and hydrogel forming microneedles

Nway Nway Aung et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

Current trends in polymer microneedle for transdermal drug delivery

Khater Ahmed Saeed AL-Japairai et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

A review of recent advances in microneedle technology for transdermal drug delivery

Rigved Nagarkar et al.

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Article Chemistry, Multidisciplinary

Colloidal crystal microneedle patch for glucose monitoring

Yi Zeng et al.

NANO TODAY (2020)

Review Pharmacology & Pharmacy

Safety Assessment of Microneedle Technology for Transdermal Drug Delivery: A Review

Dan Dan Zhu et al.

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Transdermal delivery of rapamycin with poor water-solubility by dissolving polymeric microneedles for anti-angiogenesis

Jinzhu Mao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Challenges and opportunities for drug delivery to the posterior of the eye

Fernando J. Cabrera et al.

DRUG DISCOVERY TODAY (2019)

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Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination

Archana V. Boopathy et al.

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Rapidly Fabricated Microneedle Arrays Using Magnetorheological Drawing Lithography for Transdermal Drug Delivery

Zhipeng Chen et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Microneedle-based delivery devices for cancer therapy: A review

Andre F. Moreira et al.

PHARMACOLOGICAL RESEARCH (2019)

Review Medicine, Research & Experimental

Microneedles: A smart approach and increasing potential for transdermal drug delivery system

Tejashree Waghule et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Article Cell Biology

Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

Kevin J. McHugh et al.

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A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring

Sanjiv Sharma et al.

ANALYTICAL METHODS (2018)

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3D printed microneedles for insulin skin delivery

Cristiane Patricia Pissinato Pere et al.

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Spatially controlled coating of continuous liquid interface production microneedles for transdermal protein delivery

Cassie L. Caudill et al.

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Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride

Eman M. Migdadi et al.

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Effect of humidity on mechanical properties of dissolving microneedles for transdermal drug delivery

Qi Lei Wang et al.

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Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats

Yang Zhang et al.

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Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening

Bianca Ciui et al.

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Design rules for a tunable merged-tip microneedle

Jungeun Lim et al.

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Clinical Evaluation of a Low-pain Long Microneedle for Subcutaneous Insulin Injection

Ghunil Lee et al.

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Analgesic Microneedle Patch for Neuropathic Pain Therapy

Xi Xie et al.

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Development of novel double-decker microneedle patches for transcutaneous vaccine delivery

Akihiko Ono et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Article Chemistry, Multidisciplinary

Cutaneous vaccination with coated microneedles prevents development of airway allergy

Akhilesh Kumar Shakya et al.

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Microneedle, bio-microneedle and bio-inspired microneedle: A review

Guojun Ma et al.

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Polymers for 3D Printing and Customized Additive Manufacturing

Samuel Clark Ligon et al.

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Drug-coated microneedles for rapid and painless local anesthesia

Sung-Hyun Baek et al.

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Rapid fabrication method of a microneedle mold with controllable needle height and width

Yen-Heng Lin et al.

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Micropore closure kinetics are delayed following microneedle insertion in elderly subjects

Megan N. Kelchen et al.

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Microneedle patches for vaccination in developing countries

Jaya Arya et al.

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Large Size Microneedle Patch to Deliver Lidocaine through Skin

Himanshu Kathuria et al.

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Management of acne scars: fulfilling our duty of care for patients

M. Sanchez Viera

BRITISH JOURNAL OF DERMATOLOGY (2015)

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Microneedles for Drug Delivery via the Gastrointestinal Tract

Giovanni Traverso et al.

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Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery

Jicheng Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Microneedles for Transdermal Biosensing: Current Picture and Future Direction

Letizia Ventrelli et al.

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Considerations in the sterile manufacture of polymeric microneedle arrays

Maeliosa T. C. McCrudden et al.

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Electro-Drawn Drug-Loaded Biodegradable Polymer Microneedles as a Viable Route to Hypodermic Injection

Raffaele Vecchione et al.

ADVANCED FUNCTIONAL MATERIALS (2014)

Article Chemistry, Analytical

Collection of Analytes from Microneedle Patches

Andrey V. Romanyuk et al.

ANALYTICAL CHEMISTRY (2014)

Article Engineering, Biomedical

Structural characterization and in-vivo reliability evaluation of silicon microneedles

Conor O'Mahony

BIOMEDICAL MICRODEVICES (2014)

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Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration

Marie G. McGrath et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Article Chemistry, Multidisciplinary

Perivascular biodegradable microneedle cuff for reduction of neointima formation after vascular injury

Kang Ju Lee et al.

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An optimized hollow microneedle for minimally invasive blood extraction

Cheng Guo Li et al.

BIOMEDICAL MICRODEVICES (2013)

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Use of Microneedle Array Devices for Continuous Glucose Monitoring: A Review

Ahmed El-Laboudi et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2013)

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Spatially discrete thermal drawing of biodegradable microneedles for vascular drug delivery

Chang Kuk Choi et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

Article Multidisciplinary Sciences

Characterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery

Yusuf K. Demir et al.

PLOS ONE (2013)

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Microneedles for drug and vaccine delivery

Yeu-Chun Kim et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Physical and chemical properties of titanium dioxide printed layers

Marcela Cerna et al.

CATALYSIS TODAY (2011)

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Micromolding for ceramic microneedle arrays

S. Bystrova et al.

MICROELECTRONIC ENGINEERING (2011)

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Suprachoroidal Drug Delivery to the Back of the Eye Using Hollow Microneedles

Samirkumar R. Patel et al.

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Dissolving Microneedle Patch for Transdermal Delivery of Human Growth Hormone

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Modification of microneedles using inkjet printing

R. D. Boehm et al.

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Pharmacokinetic and Pharmacodynamic Evaluation of Insulin Dissolving Microneedles in Dogs

Keizo Fukushima et al.

DIABETES TECHNOLOGY & THERAPEUTICS (2010)

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Ryan F. Donnelly et al.

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Dissolving polymer microneedle patches for influenza vaccination

Sean P. Sullivan et al.

NATURE MEDICINE (2010)

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Minimally Invasive Insulin Delivery in Subjects with Type 1 Diabetes Using Hollow Microneedles

Jyoti Gupta et al.

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Microporation applications for enhancing drug delivery

Ajay K. Banga

EXPERT OPINION ON DRUG DELIVERY (2009)

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Silica needle template fabrication of metal hollow microneedle arrays

M. W. Zhu et al.

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In vivo assessment of safety of microneedle arrays in human skin

Suzanne M. Bal et al.

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Coated microneedles for transdermal delivery

Harvinder S. Gill et al.

JOURNAL OF CONTROLLED RELEASE (2007)

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A PZT insulin pump integrated with a silicon microneedle array for transdermal drug delivery

Bin Ma et al.

MICROFLUIDICS AND NANOFLUIDICS (2006)

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Sugar micro needles as transdermic drug delivery system

T Miyano et al.

BIOMEDICAL MICRODEVICES (2005)

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Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies

DV McAllister et al.

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