期刊
MOLECULES
卷 26, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/molecules26247466
关键词
neural progenitor cells (NPCs); schisandrin A; ischemic brain injury; stroke; neural regeneration; cell division control protein 42 (Cdc42)
The study demonstrates that Schisandrin A enhances the proliferation and differentiation of neural progenitor cells, possibly by regulating Cdc42 to control cytoskeletal rearrangement and cell polarization, offering new hope for late recovery from stroke.
Schisandrin A (SCH) is a natural bioactive phytonutrient that belongs to the lignan derivatives found in Schisandra chinensis fruit. This study aims to investigate the impact of SCH on promoting neural progenitor cell (NPC) regeneration for avoiding stroke ischemic injury. The promoting effect of SCH on NPCs was evaluated by photothrombotic model, immunofluorescence, cell line culture of NPCs, and Western blot assay. The results showed that neuron-specific class III beta-tubulin (Tuj1) was positive with Map2 positive nerve fibers in the ischemic area after using SCH. In addition, Nestin and SOX2 positive NPCs were significantly (p < 0.05) increased in the penumbra and core. Further analysis identified that SCH can regulate the expression level of cell division control protein 42 (Cdc42). In conclusion, our findings suggest that SCH enhanced NPCs proliferation and differentiation possible by Cdc42 to regulated cytoskeletal rearrangement and polarization of cells, which provides new hope for the late recovery of stroke.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据