相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Chlorpromazine, an antipsychotic agent, induces G2/M phase arrest and apoptosis via regulation of the PI3K/AKT/mTOR-mediated autophagy pathways in human oral cancer
An-Jie Jhou et al.
BIOCHEMICAL PHARMACOLOGY (2021)
Drug resistant Tuberculosis: A review
Jessy Lallungawi Khawbung et al.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES (2021)
FDA approves first EGFR exon 20 targeted kinase inhibitor
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2021)
Cancer metabolism: looking forward
Inmaculada Martinez-Reyes et al.
NATURE REVIEWS CANCER (2021)
Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells
Annika Klimpel et al.
FEBS JOURNAL (2021)
Antifungal activity of promethazine and chlorpromazine against planktonic cells and biofilms of Cryptococcus neoformans/Cryptococcus gattii complex species
Raimunda Samia Nogueira Brilhante et al.
MEDICAL MYCOLOGY (2020)
One-Pot Regioselective Synthesis of Some Novel Isoxazole-Phenothiazine Hybrids and Their Antibacterial Activity
V. Guguloth et al.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2020)
Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
Elizabeth M. Grimsey et al.
MBIO (2020)
Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity
Iuliana-Monica Moise et al.
BIOORGANIC CHEMISTRY (2020)
Combretastatins: An Overview of Structure, Probable Mechanisms of Action and Potential Applications
Gokce Seker Karatoprak et al.
MOLECULES (2020)
Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents
Nourah A. Al Zahrani et al.
MOLECULES (2020)
Comprehensive Review on Alzheimer's Disease: Causes and Treatment
Zeinab Breijyeh et al.
MOLECULES (2020)
Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review
Michal Otreba et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2020)
Thioridazine Enhances P62-Mediated Autophagy and Apoptosis Through Wnt/-Catenin Signaling Pathway in Glioma Cells
Cheng-Wei Chu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies
Rajkumar Reddyrajula et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A
Jean-Baptiste Garsi et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
Design, Synthesis, and Structural Characterization of Novel Diazaphenothiazines with 1,2,3-Triazole Substituents as Promising Antiproliferative Agents
Beata Morak-Mlodawska et al.
MOLECULES (2019)
Design, Synthesis and Characterisation of Novel Phenothiazine-Based Triazolopyridine Derivatives: Evaluation of Anti-Breast Cancer Activity on Human Breast Carcinoma
Tanisha Sachdeva et al.
CHEMISTRYSELECT (2019)
Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells
Nan Liu et al.
INVESTIGATIONAL NEW DRUGS (2019)
Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options
Jeffrey L. Cummings et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Phenothiazine and amide-ornamented dihydropyridines via a molecular hybridization approach: design, synthesis, biological evaluation and molecular docking studies
Ramar Sivaramakarthikeyan et al.
NEW JOURNAL OF CHEMISTRY (2019)
Do phenothiazines possess antimicrobial and efflux inhibitory properties?
Elizabeth M. Grimsey et al.
FEMS MICROBIOLOGY REVIEWS (2019)
Drug resistance and combating drug resistance in cancer
Xuan Wang et al.
CANCER DRUG RESISTANCE (2019)
Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity
Marhiah C. Montoya et al.
ACS INFECTIOUS DISEASES (2018)
Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo
Ardeshir Rineh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)
Success stories of natural product-based hybrid molecules for multi factorial diseases
Shalki Choudhary et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)
Antiproliferative Phenothiazine Hybrids as Novel Apoptosis Inducers against MCF-7 Breast Cancer
Jun-Xia Zhang et al.
MOLECULES (2018)
New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents
Mayank Kumar Sharma et al.
SCIENTIFIC REPORTS (2018)
Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules
Mostafa M. Ghorab et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Novel Thiazolo[5,4-b] phenothiazine Derivatives: Synthesis, Structural Characterization, and In Vitro Evaluation of Antiproliferative Activity against Human Leukaemia
Balazs Brem et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages
Inigo Ruiz de Azua et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
N-Heterocyclic (4-Phenylpiperazin-1-yl)methanones Derived from Phenoxazine and Phenothiazine as Highly Potent Inhibitors of Tubulin Polymerization
Helge Prinz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures
Elizabeth H. Kellogg et al.
JOURNAL OF MOLECULAR BIOLOGY (2017)
Molecular diversity of phenothiazines: design and synthesis of phenothiazine-dithiocarbamate hybrids as potential cell cycle blockers
Dong-Jun Fu et al.
MOLECULAR DIVERSITY (2017)
Diagnosing antimicrobial resistance
Carey-Ann D. Burnham et al.
NATURE REVIEWS MICROBIOLOGY (2017)
Design, synthesis and antiproliferative activity of novel phenothiazine-1,2,3-triazole analogues
Xiao-Hua Ma et al.
JOURNAL OF CHEMICAL RESEARCH (2017)
Attaching the NorA Efflux Pump Inhibitor INF55 to Methylene Blue Enhances Antimicrobial Photodynamic Inactivation of Methicillin-Resistant Staphylococcus aureus in Vitro and in Vivo
Ardeshir Rineh et al.
ACS INFECTIOUS DISEASES (2017)
Mechanisms of Tubulin Binding Ligands to Target Cancer Cells: Updates on their Therapeutic Potential and Clinical Trials
Bhupinder Kumar et al.
CURRENT CANCER DRUG TARGETS (2017)
Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents
Alina Ghinet et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Hybrid molecules: The privileged scaffolds for various pharmaceuticals
Shaveta et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)
An overview of molecular hybrids in drug discovery
Gervais Berube
EXPERT OPINION ON DRUG DISCOVERY (2016)
Combination therapeutics in complex diseases
Bing He et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)
Design, Synthesis, and Evaluation of Novel Hybrid Efflux Pump Inhibitors for Use against Mycobacterium tuberculosis
Malkeet Kumar et al.
ACS INFECTIOUS DISEASES (2016)
Pharmacological exploitation of the phenothiazine antipsychotics to develop novel antitumor agents-A drug repurposing strategy
Chia-Hsien Wu et al.
SCIENTIFIC REPORTS (2016)
Phenothiazine-based CaaX competitive inhibitors of human farnesyltransferase bearing a cysteine, methionine, serine or valine moiety as a new family of antitumoral compounds
Gina-Mirabela Dumitriu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Design of new phenothiazine-thiadiazole hybrids via molecular hybridization approach for the development of potent antitubercular agents
Jurupula Ramprasad et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
Method for the Synthesis of Phenothiazines via a Domino Iron-Catalyzed C-S/C-N Cross-Coupling Reaction
Weiye Hu et al.
JOURNAL OF ORGANIC CHEMISTRY (2015)
Repurposing the Antipsychotic Trifluoperazine as an Antimetastasis Agent
Ashleigh Pulkoski-Gross et al.
MOLECULAR PHARMACOLOGY (2015)
Characterization of the type 2 NADH:menaquinone oxidoreductases from Staphylococcus aureus and the bactericidal action of phenothiazines
Lici A. Schurig-Briccio et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2014)
Incorporation of triphenylphosphonium functionality improves the inhibitory properties of phenothiazine derivatives in Mycobacterium tuberculosis
Elyse A. Dunn et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Rational design, synthesis and antitubercular evaluation of novel 2-(trifluoromethyl)phenothiazine-[1,2,3]triazole hybrids
Dinesh Addla et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
Alejandro Gutierrez et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Design and synthesis of tacrine-phenothiazine hybrids as multitarget drugs for Alzheimer's disease
Ai-ling Hui et al.
MEDICINAL CHEMISTRY RESEARCH (2014)
Immobilization of Homogeneous Monomeric, Oligomeric and Fibrillar Aβ Species for Reliable SPR Measurements
Daniel Frenzel et al.
PLOS ONE (2014)
The Role of Histamine H1 and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study
Yusuke Ohsawa et al.
ALLERGOLOGY INTERNATIONAL (2014)
Synthesis and pharmacological investigation of new N-hydroxyalkyl-2-aminophenothiazines exhibiting marked MDR inhibitory effect
Daniella Takacs et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems
Sultan Darvesh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents
Cristina-Maria Abuhaie et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
Synthesis, antiproliferative activity and tubulin targeting effect of acridinone and dioxophenothiazine derivatives
Valerie Verones et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach
Thomas J. Montine et al.
ACTA NEUROPATHOLOGICA (2012)
Heterocycles 27. Microwave Assisted Synthesis and Antitumour Activity of Novel Phenothiazinyl-Thiazolyl-Hydrazine Derivatives
Adriana Ignat et al.
ARCHIV DER PHARMAZIE (2012)
New farnesyltransferase inhibitors in the phenothiazine series
Dalila Belei et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors
Lavinia Baciu-Atudosie et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
Foundation review: Phenothiazine: the seven lives of pharmacology's first lead structure
Maike J. Ohlow et al.
DRUG DISCOVERY TODAY (2011)
N-Acylaminophenothiazines: Neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease
Gema C. Gonzalez-Munoz et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
N-Benzoylated Phenoxazines and Phenothiazines: Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization
Helge Prinz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases
Gema C. Gonzalez-Munoz et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)
Multiple non-psychiatric effects of phenothiazines: A review
Gangopadhyay Sudeshna et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
Synthesis and structure-activity relationships of phenothiazine carboxylic acids having pyrimidine-dione as novel histamine H1 antagonists
Katsumi Kubota et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation
George P. Tegos et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Gene-Environment Interactions in the Development of Complex Disease Phenotypes
Rosemarie Ramos et al.
International Journal of Environmental Research and Public Health (2008)
Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps
GP Tegos et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2006)
The endocannabinoid system as an emerging target of pharmacotherapy
Pal Pacher et al.
PHARMACOLOGICAL REVIEWS (2006)
Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes - Phenothiazines and leukemia
Z Zhelev et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2004)
New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives
GA Silva et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Cannabinoid pharmacological properties common to other centrally acting drugs
JL Wiley et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2003)
Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum
J Guan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
A structural variation for MurB:: X-ray crystal structure of Staphylococcus aureus UDP-N-acetylenolpyruvylglucosamine reductase (MurB)
TE Benson et al.
BIOCHEMISTRY (2001)