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Article
Biochemistry & Molecular Biology
Yu-Ming Liu et al.
Summary: Two rare guanidine-type alkaloids were isolated from Buthus martensii Karsch, with compound 1 showing the most potent inhibition on AChE and BChE. The study provides new evidence for the further development and utilization of B. martensii in health and pharmaceutical products.
Review
Biochemistry & Molecular Biology
Fei-Xuan Wang et al.
Summary: This review focuses on the potential of certain natural aporphine alkaloids in preventing and treating metabolic syndrome and its components. The protective effects of these alkaloids on various risk factors of metabolic syndrome are highlighted, along with discussions on their impact on insulin resistance, cardiovascular diseases, obesity, kidney damage, and other related issues. The review also delves into the potential mechanisms of actions by these alkaloids in addressing metabolic syndrome.
Article
Biochemistry & Molecular Biology
Lingli Cui et al.
Summary: This study explored the diversity of endophytic fungal community within H. serrata and its correlation with HupA production. The richness and diversity of endophytic fungi in leaves and stems were higher than in roots, with 11 genera positively correlated with HupA content. The research provides insights into screening more effective strains for HupA production.
Review
Biochemistry & Molecular Biology
Xianqin Wei et al.
Summary: Pyrrolizidine alkaloids (PAs) are a common group of secondary metabolites in plants, known for their toxicity to humans and animals, but also show potential for therapeutic applications.
Article
Biochemistry & Molecular Biology
Neha Gupta et al.
Summary: By studying alkaloid compounds from Holarrhena pubescens, researchers identified three compounds with significant binding affinity to ECDGC-C and potential to inhibit the binding of STa to ECD.
Review
Biochemistry & Molecular Biology
Sharna-kay Daley et al.
Summary: The paper presents an overview of the established role of alkaloids in drug discovery, the use of more sustainable chemicals and biological approaches, and the implementation of information systems to address current challenges in meeting global disease needs. It also discusses the necessity for a new international paradigm in the Fourth Industrial Revolution and the Quintuple Helix era for the treatment of multidrug resistant organisms, rare and neglected tropical diseases.
Article
Biochemistry & Molecular Biology
Sylvester I. Omoruyi et al.
Summary: Parkinson's disease is a common neurodegenerative disease with a lack of effective treatment options. Studies have shown that compounds from the Amaryllidaceae plant family may have neuroprotective potential for treating Parkinson's disease.
Article
Biochemistry & Molecular Biology
Elena Pruteanu et al.
Summary: A convenient molecular editing strategy based on radical mediated C-C bond formation has been developed for modification of available ent-kauranic natural scaffolds. The study shows that this strategy can lead to the synthesis of extended diterpenes with broad structural diversity and artificial diterpene-alkaloid hybrids, some of which exhibit significant cytotoxicity and promising selectivity indexes. These findings provide a solid foundation for further research on the synthesis of derivatives based on available natural product templates.
Review
Biochemistry & Molecular Biology
Kamal P. Pandey et al.
Summary: Bisindoles are structurally complex dimers with stronger biological activity, making them attractive targets for synthesis. This review discusses the isolation, bioactivity, biosynthesis, and synthesis of bisindoles from various Alstonia species.
Article
Biochemistry & Molecular Biology
Burtram C. Fielding et al.
