期刊
MOLECULES
卷 26, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules26196019
关键词
monoamine oxidase; cancer; metastasis; inhibitors; QSAR; pharmacophore
资金
- Deanship of Scientific Research at the University of Jordan [23249, 23253]
- King Abdullah II Fund for Development [2/2020]
- Abdul Hameed Shoman Scientific Research Support Fund [10/2020]
Monoamine oxidases (MAOs) are oxidative enzymes responsible for converting biogenic amines into aldehydes and ketones. Distorted activity of MAOs has been linked to neurological diseases, and recent studies have found unexpected roles of MAOs in tumor progression and metastasis. Chemical inhibition of MAOs may be a valuable therapeutic approach for cancer treatment.
Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.
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