4.6 Article

Biophysical and Biological Tools to Better Characterize the Stability, Safety and Efficacy of a Cosmeceutical for Acne-Prone Skin

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MOLECULES
卷 27, 期 4, 页码 -

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MDPI
DOI: 10.3390/molecules27041255

关键词

acne-prone skin; Cutibacterium acnes; rheological properties; keratinocytes; human reconstructed 3D models; biofilm; antimicrobial effectiveness; anti-inflammatory activity; preservative system; cosmeceutical

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This study focused on the rheological characterization and quality assurance of an anti-acne serum, and the evaluation of its biological effectiveness. The results showed that the serum had solid-like behavior and pseudoplastic properties. The serum was non-cytotoxic and non-irritant, with good antimicrobial and anti-inflammatory activity, indicating its effectiveness for acne-prone skin treatment.
(1) Background: Acne is a widespread skin disease, especially among adolescents. Following the COVID-19 pandemic and the use of masks, the problem has been affecting a greater number of people, and the attention of the skin care beauty routine cosmetics has been focused on the Maskne, caused by the sebum excretion rate (SER) that stimulates microbial proliferation. (2) Methods: the present study was focused on the rheological characterization and quality assurance of the preservative system of an anti-acne serum. The biological effectiveness (cytotoxicity-skin and eye irritation-antimicrobial, biofilm eradication and anti-inflammatory activity) was evaluated in a monolayer cell line of keratinocytes (HaCaT) and on 3D models (reconstructed human epidermis, RHE and human reconstructed corneal epithelium, HCE). The Cutibacterium acnes, as the most relevant acne-inducing bacterium, is chosen as a pro-inflammatory stimulus and to evaluate the antimicrobial activity of the serum. (3) Results and Conclusions: Rheology allows to simulate serum behavior at rest, extrusion and application, so the serum could be defined as having a solid-like behavior and being pseudoplastic. The preservative system is in compliance with the criteria of the reference standard. Biological effectiveness evaluation shows non-cytotoxic and irritant behavior with a good antimicrobial and anti-inflammatory activity of the formulation, supporting the effectiveness of the serum for acne-prone skin treatment.

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