Insight into Potential Anticancer Activity of Algal Flavonoids: Current Status and Challenges

Flavonoids are some of the most precious phytochemicals, believed to be found largely in terrestrial plants. With the advancement of phytochemical research and marine bioprospecting, flavonoids have also been reported by the research of microalgae and macroalgae. High growth rate with minimal nutritional and growth requirement, saving arable land and rich metabolic profile make microalgae an excellent repertoire of novel anticancer compounds, such as flavonoids. In addition, marine algae, especially seaweeds contain different types of flavonoids which are assumed to have unique chemical structures and bioactivities than their terrestrial counterparts. Flavonoids are not only good antioxidants but also have the abilities to kill cancer cells by inducing apoptosis and autophagy. However, the study of the anticancer properties of flavonoids is largely limited to terrestrial plants. This review offers an insight into the distribution of different classes of flavonoids in eukaryotic microalgae, cyanobacteria and seaweeds with their possible anticancer activities. In addition, extraction and purification methods of these flavonoids have been highlighted. Finally, prospects and challenges to use algal flavonoids as anticancer agents have been discussed.

Automated summary

Flavonoids, important plant chemicals, are found not only in terrestrial plants but also in microalgae and seaweeds, offering potential for novel anticancer compounds with unique chemical structures and bioactivities. Flavonoids act as antioxidants and have the ability to induce apoptosis and autophagy in cancer cells. However, research on the anticancer properties of flavonoids is mainly focused on terrestrial plants.