期刊
MOLECULES
卷 27, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules27020405
关键词
caffeine; greener HPTLC; paracetamol; simultaneous determination; validation
资金
- Taif University Researchers Supporting Project [TURSP-2020/124]
- Taif University, Taif, Saudi Arabia
- TURSP
A rapid, sensitive, and greener reversed-phase HPTLC approach was developed for the simultaneous determination of caffeine and paracetamol in commercial formulations. This approach showed superior sensitivity, accuracy, precision, and robustness compared to the greener normal-phase HPTLC technique.
There has been no assessment of the greenness of the described analytical techniques for the simultaneous determination (SMD) of caffeine and paracetamol. As a result, in comparison to the greener normal-phase high-performance thin-layer chromatography (HPTLC) technique, this research was conducted to develop a rapid, sensitive, and greener reversed-phase HPTLC approach for the SMD of caffeine and paracetamol in commercial formulations. The greenness of both techniques was calculated using the AGREE method. For the SMD of caffeine and paracetamol, the greener normal-phase and reversed-phase HPTLC methods were linear in the 50-500 ng/band and 25-800 ng/band ranges, respectively. For the SMD of caffeine and paracetamol, the greener reversed-phase HPTLC approach was more sensitive, accurate, precise, and robust than the greener normal-phase HPTLC technique. For the SMD of caffeine paracetamol in commercial PANEXT and SAFEXT tablets, the greener reversed-phase HPTLC technique was superior to the greener normal-phase HPTLC approach. The AGREE scores for the greener normal-phase and reversed-phase HPTLC approaches were estimated as 0.81 and 0.83, respectively, indicated excellent greenness profiles for both analytical approaches. The greener reversed-phase HPTLC approach is judged superior to the greener normal-phase HPTLC approach based on numerous validation parameters and pharmaceutical assays.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据