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Wim P. Burmeister et al.
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Computational Rationale for the Selective Inhibition of the Herpes Simplex Virus Type 1 Uracil-DNA Glycosylase Enzyme
Umraan Hendricks et al.
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Thidarat Suksangpleng et al.
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L. D. Weeks et al.
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Hua Zhang et al.
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Celeste Sele et al.
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Wanjuan Yang et al.
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A. D. Bulgar et al.
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Norbert Schormann et al.
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Breeana C. Grogan et al.
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Manunya Nuth et al.
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UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
Henrik Sahlin Pettersen et al.
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TSAR, a new graph-theoretical approach to computational modeling of protein side-chain flexibility: Modeling of ionization properties of proteins
Oleg V. Stroganov et al.
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Suhman Chung et al.
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Uracil in DNA and its processing by different DNA glycosylases
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Base excision DNA repair
D. O. Zharkov
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Synthetic lethality with the dut defect in Escherichia coli reveals layers of DNA damage of increasing complexity due to uracil incorporation
Helen Ting et al.
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Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase
Golo Kronenberg et al.
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Effects of vaccinia virus uracil DNA glycosylase catalytic site and deoxyuridine triphosphatase deletion mutations individually and together on replication in active and quiescent cells and pathogenesis in mice
Frank S. De Silva et al.
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Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA
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Enzymatic capture of an extrahelical thymine in the search for uracil in DNA
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Bin Liu et al.
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Uracil in DNA-general mutagen, but normal intermediate in acquired immunity
Bodil Kavli et al.
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Daniel J. Krosky et al.
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Yu Lin Jiang et al.
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A comparative study of uracil-DNA glycosylases from human and herpes simplex virus type 1
K Krusong et al.
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Vaccinia virus uracil DNA glycosylase interacts with the A20 protein to form a heterodimeric processivity factor for the viral DNA polymerase
ES Stanitsa et al.
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Uracil-directed ligand tethering: An efficient strategy for uracil DNA glycosylase (UNG) inhibitor development
YL Jiang et al.
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HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle
S Priet et al.
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Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair
EA Kouzminova et al.
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The merits of bipartite transition-state mimics for inhibition of uracil DNA glycosylase
YL Jiang et al.
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Optimisation of the surface electrostatics as a strategy for cold adaptation of uracil-DNA N-glycosylase (UNG) from Atlantic cod (Gadus morhua)
E Moe et al.
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Characterisation of the substrate specificity of homogeneous vaccinia virus uracil-DNA glycosylase
N Scaramozzino et al.
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Importance of uracil DNA glycosylase in Pseudomonas aeruginosa and Mycobacterium smegmatis, G+C-rich bacteria, in mutation prevention, tolerance to acidified nitrite, and endurance in mouse macrophages
J Venkatesh et al.
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FS De Silva et al.
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Uracil in DNA - occurrence, consequences and repair
HE Krokan et al.
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B Kavli et al.
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Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication
H Nilsen et al.
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Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects
SS Parikh et al.
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