期刊
MOLECULES
卷 27, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules27031122
关键词
Hf(OTf)(4); Mannich base; three-component reaction; carbamate; reaction mechanism
资金
- National Natural Science Foundation of China [21961013]
- Innovation Foundation of JXSTNU [YC2020-X18]
Hafnium(IV) triflate (Hf(OTf)(4)) has been identified as a potent catalyst for the direct three-component synthesis of beta-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provides easy access to a variety of carbamate-protected Mannich bases. Mechanistic investigation reveals that the three-component reaction proceeds through sequential aldol condensation and aza-Michael addition, rather than the Mannich-type pathway.
Hafnium(IV) triflate (Hf(OTf)(4)) has been identified as a potent catalyst for the direct three-component synthesis of beta-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据