期刊
MOLECULES
卷 26, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/molecules26216598
关键词
Daphne; diterpenoid; bioactivities
资金
- National Natural Science Foundation of the People's Republic of China [81703672]
- New Interdisciplinary Subjects of Pudong New District Health Committee [PWXx2020-04]
- Projects of Shanghai Pudong New District Academic Leaders [PWRd2021-10]
- Excellent Youth Medical Talents Training Program of Pudong Health Bureau of Shanghai [PWRq2020-66]
- Clinical Chinese Medicine Plateau Discipline Construction Project of Shanghai Pudong New District Health Committee [PDZY-2018-0604]
- Shanghai three-year Action Plan to further accelerate the development of Chinese Medicine [ZY (2018-2020)-CCCX-2008]
- Key Disciplines Group of Shanghai Pudong New District Health Committee [PWZwq2017-16]
Plants of the genus Daphne contain abundant natural diterpenoids with various bioactivities such as anticancer, anti-inflammatory, and anti-HIV effects. Studies have also summarized the structure-activity relationship to facilitate the synthesis and optimization of drugs.
There are abundant natural diterpenoids in the plants of the genus Daphne from the Thymelaeaceae family, featuring a 5/7/6-tricyclic ring system and usually with an orthoester group. So far, a total of 135 diterpenoids has been isolated from the species of the genus Daphne, which could be further classified into three main types according to the substitution pattern of ring A and oxygen-containing functions at ring B. A variety of studies have demonstrated that these compounds exert a wide range of bioactivities both in vitro and in vivo including anticancer, anti-inflammatory, anti-HIV, antifertility, neurotrophic, and cholesterol-lowering effects, which is reviewed herein. Meanwhile, the fascinating structure-activity relationship is also concluded in this review in the hope of providing an easy access to available information for the synthesis and optimization of efficient drugs.
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