期刊
MOLECULES
卷 26, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/molecules26216751
关键词
vinylindoles; cycloaddition; ortho-quinone methide; chiral phosphoric acid; asymmetric organocatalysis
资金
- National Natural Science Foundation of China [22125104, 21831007]
- Natural Science Foundation of Jiangsu Province [BK20201018]
- Natural Science Foundation of Xuzhou City [KC21021]
- High-level Innovative and Entrepreneurial Talents Introduction Plan of Jiangsu Province
- Natural Science Foundation of JSNU [19XSRX010]
The catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides using chiral phosphoric acid as the catalyst resulted in a series of indole-containing chroman derivatives with high structural diversity, overall high yields (up to 98%), good diastereoselectivities (up to 93:7 dr), and moderate to excellent enantioselectivities (up to 98% ee).
Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural diversity in overall high yields (up to 98%), good diastereoselectivities (up to 93:7 dr) and moderate to excellent enantioselectivities (up to 98% ee). This approach not only enriches the chemistry of catalytic asymmetric cycloadditions involving 3-vinylindoles but is also useful for synthesizing chiral chroman derivatives.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据