期刊
MOLECULES
卷 27, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/molecules27010158
关键词
antioxidant activity; radical-scavenging activity; liquid chromatography; cyclitols; flavonoids; glutathione
资金
- Foundation for Polish Science [FNP POIR.04.04.00-00-1792/18-00]
- European Union under the European Regional Development Fund
The conditions for determining the antioxidant properties of cyclitols, flavanones, and glutathione have been identified. The low antioxidative properties of cyclitols compared to flavanones and glutathione were revealed. However, the methyl-ether derivatives of cyclitols showed a significant increase in the antioxidative properties of glutathione.
The conditions for determining the antioxidant properties of cyclitols (d-pinitol, l-quebrachitol, myo-, l-chiro-, and d-chiro-inositol), selected flavanones (hesperetin, naringenin, eriodictyol, and liquiritigenin) and glutathione by spectrophotometric methods-CUPRAC and with DPPH radical, and by a chromatographic method DPPH-UHPLC-UV, have been identified. Interactions of the tested compounds and their impact on the ox-red properties were investigated. The RSA (%) of the compounds tested was determined. Very low antioxidative properties of cyclitols, compared with flavanones and glutathione alone, were revealed. However, a significant increase in the determined antioxidative properties of glutathione by methyl-ether derivatives of cyclitols (d-pinitol and l-quebrachitol) was demonstrated for the first time. Thus, cyclitols seem to be a good candidate for creating drugs for the treatment of many diseases associated with reactive oxygen species (ROS) generation.
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