☆ 4.6 Review

Genistein-Opportunities Related to an Interesting Molecule of Natural Origin

MOLECULES (2022)

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Review Cardiac & Cardiovascular Systems

Effect of Genistein Intake on Some Cardiovascular Risk Factors: An Updated Systematic Review and Meta-analysis

Atefeh Amerizadeh et al.

Summary: Genistein intake significantly reduces total cholesterol, LDL-C, and SBP, but has no significant effect on DBP, HDL-C, TG, BMI, and body weight. Postmenopausal women with metabolic syndrome have a better response in reducing LDL-C and SBP. Genistein intake for more than 6 months has a greater effect on lowering cholesterol, SBP, and DBP, and increasing TG and LDL-C.

CURRENT PROBLEMS IN CARDIOLOGY (2022)

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Article Biochemical Research Methods

Rapid screening and purification of potential inhibitors fromMedicago sativaby ultrafiltration-liquid chromatography combined with stepwise flow rate counter-current chromatography

Wanchao Hou et al.

Summary: The study successfully screened and isolated neuraminidase, lipoxidase, and lactate dehydrogenase inhibitors from Medicago sativa using a combination of ultrafiltration-liquid chromatography-mass spectrometry (UF-LC-MS) and stepwise flow rate counter-current chromatography (CCC). The identified compounds quercetin, genistein, and formononetin showed potential as inhibitors for the respective enzymes. The novel approach demonstrated a powerful tool for identifying bioactive ingredients from complex matrices, providing a useful platform for large-scale production of nutraceutical ingredients.

PHYTOCHEMICAL ANALYSIS (2021)

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Article Chemistry, Medicinal

Effect of flavonoids in preclinical models of experimental obesity

Luana M. Cercato et al.

Summary: Oral supplementation of flavonoids can reduce body weight, blood glucose, glucose tolerance, insulin resistance, and fat and lipid profiles in animal models of obesity. These effects are mainly related to the antioxidant and anti-inflammatory actions of flavonoids, exerted through modulation of different pathways.

PHARMANUTRITION (2021)

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Article Food Science & Technology

Significance of storage study on ACE inhibitory, antioxidative, antimicrobial activities, and biotransformation of isoflavones of functional fermented soy-based beverage

Trupti Undhad et al.

Summary: This study prepared plant protein beverages with potential benefits through lactobacilli fermentation, demonstrating antioxidative, antimicrobial, and ACE inhibitory activities, while maintaining high storage stability. During the 15-day storage period, the biofunctional properties of these fermented beverages slightly decreased in the first 5 days and underwent biotransformation of soy isoflavones.

JOURNAL OF FOOD PROCESSING AND PRESERVATION (2021)

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Article Biochemistry & Molecular Biology

Combination of metformin and genistein alleviates non-alcoholic fatty liver disease in high -fat diet-fed mice

Fahimeh Zamani-Garmsiri et al.

Summary: The combination therapy of MET and GEN showed significant benefits against NAFLD in HFD-fed mice, reducing body weight, liver weight, fasting blood glucose levels, liver triglyceride levels, and inflammation while regulating key genes and pathways related to lipid metabolism, glucose production, and inflammation.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2021)

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Article Environmental Sciences

Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens

Xiaona Gao et al.

Summary: The study found that genistein (GEN) can alleviate the pathological damage, hepatic steatosis, and insulin resistance induced by a high-energy low-protein diet in laying hens, while bisphenol A (BPA) can exacerbate NAFLD symptoms and suppress ER alpha levels in the liver, with GEN being able to reverse this effect.

ENVIRONMENTAL POLLUTION (2021)

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Article Multidisciplinary Sciences

Thermoresponsive GenisteinNLC-dexamethasone-moxifloxacin multi drug delivery system in lens capsule bag to prevent complications after cataract surgery

Tingyu Yan et al.

Summary: A new temperature-sensitive drug delivery system was developed to reduce inflammation, infection, and secondary cataract after cataract surgery. Characterizations and release profiles of the system were studied, showing effectiveness in vitro functions. This system has the potential to reduce the need for eye drops and prevent complications post-surgery.

SCIENTIFIC REPORTS (2021)

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Review Pharmacology & Pharmacy

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

Liuqing Yang et al.

Summary: Oxidative stress plays a role in ovarian aging and contributes to the development of other related etiologies. Natural antioxidants like quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms, suggesting their potential as therapeutic interventions for delaying ovarian aging.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH)

Sudaporn Pummoung et al.

Summary: Genistein has protective effects on NASH in estrogen deficient rats, reducing hepatic lipid accumulation and apoptosis by modulating the expression of PPAR gamma and adiponectin.

ANTIOXIDANTS (2021)

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Article Agriculture, Multidisciplinary

A metabolomics approach to evaluate post-fermentation enhancement of daidzein and genistein in a green okara extract

Sulagna Gupta et al.

Summary: Okara, a by-product of the tofu and soymilk industries, was found to yield better results in total phenolic and flavonoid content after fermentation with Rhizopus oligosporus. Analysis showed a shift in isoflavones from glucoside forms to their respective aglycone forms post-fermentation, with fermented extracts having higher concentrations of genistein and daidzein, which are beneficial for health. The study suggests that fermented okara could be a sustainable solution for producing natural bioactive isoflavonoids.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2021)

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Article Biochemistry & Molecular Biology

Influence of Genistein on Hepatic Lipid Metabolism in an In Vitro Model of Hepatic Steatosis

Lena Seidemann et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) is a leading cause of end-stage liver disease, with unsatisfactory pharmacological treatment options available. Genistein, a soy isoflavone, shows beneficial effects on lipid metabolism and may be a candidate for NAFLD treatment. In an in vitro model, genistein treatment affects PPAR alpha and SREBP-1c signaling pathways, playing a significant role in hepatic lipid metabolism.

MOLECULES (2021)

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Article Gastroenterology & Hepatology

Evaluating the prevalence and severity of NAFLD in primary care: the EPSONIP study protocol

Patrik Nasr et al.

Summary: The study aims to evaluate the prevalence and severity of NAFLD in patients with T2DM, providing clinicians with better diagnostic tools.

BMC GASTROENTEROLOGY (2021)

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Article Public, Environmental & Occupational Health

Low health literacy is associated with higher risk of type 2 diabetes: a cross-sectional study in Germany

Daniel Tajdar et al.

Summary: The study found that individuals with inadequate self-reported health literacy have an increased risk of developing type 2 diabetes. It is suggested that educational programs should be provided for those with high diabetes risk and inadequate health literacy to improve diabetes knowledge and reduce behavioral risk factors.

BMC PUBLIC HEALTH (2021)

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Article Food Science & Technology

Effects of okara and vitamin B2 bioenrichment on the functional properties and in vitro digestion of fermented soy milk

Jing-Yu Feng et al.

Summary: By immobilizing probiotics and okara for soy milk fermentation, the bioconversion rate of isoflavones and the production of vitamin B2 can be enhanced, leading to increased antioxidant properties. The study highlights the importance of okara in the microstructural design of soy milk.

FOOD RESEARCH INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Poly(chitosan-ester-ether-urethane) Hydrogels as Highly Controlled Genistein Release Systems

Martyna Zagorska-Dziok et al.

Summary: Polymeric hydrogels play an increasingly important role in medicine, pharmacy, and cosmetology due to their favorable physicochemical properties and biocompatibility. This study synthesized new poly(chitosan-ester-ether-urethane) hydrogels and studied the kinetic release of genistein from these biomaterials. The developed hydrogels show non-toxicity to skin cells and a relatively highly controlled release profile of genistein.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Physiologically Active Molecules and Functional Properties of Soybeans in Human Health-A Current Perspective

Il-Sup Kim et al.

Summary: Soybeans not only provide nutrients, but also contain various phytochemical substances that promote health and have positive effects in preventing chronic diseases and treating conditions like cancer.

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Madalina Neacsu et al.

Summary: Apios americana, a North American plant, shows potential as a commercially viable crop in Northern Europe due to its resistance to extreme climate and high nutritional quality. Analysis of A. americana tubers from Southern and Northern UK sites revealed they are a complete source of amino acids, rich in protein, fiber, micronutrients, and bioactive phytochemicals. Additionally, leaves and rhizomes were found to have higher protein and fiber content than tubers, with leaves also being a good source of anthocyanins. Cultivation of A. americana has great potential for human nutrition, diet diversification, and livestock diets in Northern European countries.

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Toll-like receptor 4: An attractive therapeutic target for acute kidney injury

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Summary: This review emphasizes the role of TLR4 signaling pathway in AKI and highlights potential compounds of natural and synthetic origin that can avert renal TLR4 signaling and offer protection against AKI in preclinical models. Targeting TLR4 and its downstream effectors could serve as an effective therapeutic intervention to prevent renal inflammation and subsequent kidney damage.

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The Potential Effects of Phytoestrogens: The Role in Neuroprotection

Justyna Gorzkiewicz et al.

Summary: Phytoestrogens have potential health benefits in reducing menopausal symptoms, osteoporosis, cardiovascular disease, and brain disease risk, while also exhibiting inhibitory effects on cancer.

MOLECULES (2021)

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Article Endocrinology & Metabolism

An association between visceral or subcutaneous fat accumulation and diabetes mellitus among Japanese subjects

Hirohide Yokokawa et al.

Summary: The study found a significant association between VFA and SFA with diabetes mellitus in Japanese subjects, especially among women. Multivariate analyses indicated that higher quartiles of VFA or SFA were positively associated with DM.

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Article Biotechnology & Applied Microbiology

Profiling of bioactives and in vitro evaluation of antioxidant and antidiabetic property of polyphenols of marine algae Padina tetrastromatica

Jayapala Naveen et al.

Summary: This study characterized and quantified the phenolics, hydrocolloids, lipids, and carotenoids of marine brown algae Padina tetrastromatica, demonstrating its rich antioxidant and antidiabetic properties.

ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS (2021)

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Review Food Science & Technology

Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases

Chan Ho Jang et al.

Summary: Fermented soybean products are widely consumed in East Asian countries and contain various beneficial compounds that can prevent and improve neurodegenerative diseases.

FOODS (2021)

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Article Integrative & Complementary Medicine

Genistein and exercise treatment reduced NASH related HDAC3, IL-13 and MMP-12 expressions in ovariectomized rats fed with high fat high fructose diet

Namthip Witayavanitkul et al.

Summary: The study found that genistein and exercise treatments improved non-alcoholic steatohepatitis by suppressing the expression of specific proteins. However, the combination therapy did not provide additional benefits.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Current Perspectives on the Physiological Activities of Fermented Soybean-Derived Cheonggukjang

Il-Sup Kim et al.

Summary: Cheonggukjang, a traditional Korean fermented dish, has emerged as a functional food with various health benefits, such as improving blood circulation and intestinal regulation. It is made without salt and contains bioactive substances that prevent atherosclerosis, heart disease, inflammation, obesity, diabetes, dementia, cancer, and osteoporosis, among other health conditions. Studies have shown that Cheonggukjang also has thrombolytic, blood pressure-lowering, lipid-lowering, antimutagenic, immunostimulatory, and antibacterial properties, as well as skin improvement benefits.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Food Science & Technology

Characterization of fermented soymilk by Schleiferilactobacillus harbinensis M1, based on the whole-genome sequence and corresponding phenotypes

Yin Zheng et al.

Summary: The use of Schleiferilactobacillus (S.) harbinensis M1 as a starter culture in fermenting soy milk has been found to significantly impact the transformation of carbohydrates, isoflavones, and proteins, as well as enhancing the antioxidant and antiproliferative effects of the soymilk.

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Article Food Science & Technology

Therapeutic effects of polyphenols in fermented soybean and black soybean products

Azin Khosravi et al.

Summary: Polyphenols act as natural antioxidants in plants, with isoflavones and anthocyanins being two main groups found in soybean and black soybean. Fermentation converts glycoside polyphenols into aglycone form, enhancing their therapeutic effects, including anti-cancer and anti-diabetes properties. Fermentation of soybean products leads to changes in the structure and composition of polyphenols, increasing their therapeutic activity.

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Article Nutrition & Dietetics

Dietary Soy Consumption and Cardiovascular Mortality among Chinese People with Type 2 Diabetes

Xiaowen Wang et al.

Summary: Randomized controlled trials have shown that consuming soy can significantly reduce the risk of cardiovascular death among individuals with diabetes. A study in Chinese adults with diabetes found that higher soy consumption was associated with a lower risk of cardiovascular death, especially from coronary heart disease and acute myocardial infarction.

NUTRIENTS (2021)

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Article Agronomy

Effects of Solid-State Fermentation with Eurotium cristatum YL-1 on the Nutritional Value, Total Phenolics, Isoflavones, Antioxidant Activity, and Volatile Organic Compounds of Black Soybeans

Yu Xiao et al.

Summary: Black soybeans processed by SSF with E. cristatum significantly increased protein, essential amino acids, and mineral contents, while also positively affecting the fatty acid composition, total phenolics, and isoflavone content. The fermented black soybeans demonstrated enhanced antioxidant activity and volatile organic compounds.

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Review Biochemistry & Molecular Biology

Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans

Il-Sup Kim

Summary: Soybeans are rich in proteins and lipids, as well as functional components such as isoflavones, which are structurally similar to estrogen and play a role in regulating estrogen in the human body. Isoflavones have diverse physiological functions, including anticancer, antioxidant, and anti-allergic effects.

ANTIOXIDANTS (2021)

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Review Biochemistry & Molecular Biology

Molecular Changes Underlying Genistein Treatment of Wound Healing: A Review

Matus Coma et al.

Summary: Estrogen plays a complex role in wound healing and cancer, with current research focusing on naturally occurring SERMs. By utilizing natural products isolated from plants, such as genistein in soy, as potential alternatives, tissue-specific effects can be achieved in a promising manner.

CURRENT ISSUES IN MOLECULAR BIOLOGY (2021)

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Article Nutrition & Dietetics

Urinary equol, but not daidzein and genistein, was inversely associated with the risk of type 2 diabetes in Chinese adults

Hong-Li Dong et al.

EUROPEAN JOURNAL OF NUTRITION (2020)

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Clinical effects of the three CFTR potentiator treatments curcumin, genistein and ivacaftor in patients with the CFTR-S1251N gating mutation

Gitte Berkers et al.

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Article Food Science & Technology

Synthesis, Characterization, and Evaluation of Genistein-Loaded Zein/Carboxymethyl Chitosan Nanoparticles with Improved Water Dispersibility, Enhanced Antioxidant Activity, and Controlled Release Property

Yu Xiao et al.

FOODS (2020)

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Mormodica charantia L. fruit and Genistein ameliorates type 2 diabetes in rats by preventing lipid accumulation, insulin resistance and enhancing beta cell function

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MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice

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Genistein modulates gene activity in psoriatic patients

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Role of dietary flavonoids in amelioration of sugar induced cataractogenesis

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ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2016)

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Article Toxicology

Phase II metabolism of the soy isoflavones genistein and daidzein in humans, rats and mice: a cross-species and sex comparison

Sebastian T. Soukup et al.

ARCHIVES OF TOXICOLOGY (2016)

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Article Biochemistry & Molecular Biology

Ameliorative effect of dietary genistein on diabetes induced hyper-inflammation and oxidative stress during early stage of wound healing in alloxan induced diabetic mice

Hyeyoon Eo et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Article Nutrition & Dietetics

Urine phyto-oestrogen metabolites are not significantly associated with risk of type 2 diabetes: the Singapore Chinese health study

Mohammad Talaei et al.

BRITISH JOURNAL OF NUTRITION (2016)

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Article Gastroenterology & Hepatology

The Prevalence and Pathobiology of Nonalcoholic Fatty Liver Disease in Patients of Different Races or Ethnicities

Harmit S. Kalia et al.

CLINICS IN LIVER DISEASE (2016)

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Article Gastroenterology & Hepatology

Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis in the United States and the Rest of the World

Mehmet Sayiner et al.

CLINICS IN LIVER DISEASE (2016)

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Article Nutrition & Dietetics

Consumption of soy foods and isoflavones and risk of type 2 diabetes: a pooled analysis of three US cohorts

M. Ding et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2016)

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Review Integrative & Complementary Medicine

A Review of Western and Traditional Chinese Medical Approaches to Managing Nonalcoholic Fatty Liver Disease

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EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

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Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes

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Potentiator synergy in rectal organoids carrying S1251N, G551D, or F508de1 CFTR mutations

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Review Chemistry, Medicinal

Soy Isoflavones and Osteoporotic Bone Loss: A Review with an Emphasis on Modulation of Bone Remodeling

Xi Zheng et al.

JOURNAL OF MEDICINAL FOOD (2016)

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Studies on the antioxidant properties of some phytoestrogens

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Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature

Mark Messina

NUTRIENTS (2016)

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Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients

Mark Messina

FORSCHENDE KOMPLEMENTARMEDIZIN (2016)

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Article Nutrition & Dietetics

Urinary isoflavonoids and risk of type 2 diabetes: a prospective investigation in US women

Ming Ding et al.

BRITISH JOURNAL OF NUTRITION (2015)

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Review Gastroenterology & Hepatology

The gut microbiome in health and in disease

Andrew B. Shreiner et al.

CURRENT OPINION IN GASTROENTEROLOGY (2015)

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Cytokines in psoriasis

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CYTOKINE (2015)

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Protective effects of genistein in homocysteine-induced endothelial cell inflammatory injury

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MOLECULAR AND CELLULAR BIOCHEMISTRY (2015)

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Flavonoid intake and the risk of age-related cataract in China's Heilongjiang Province

Yingna Ma et al.

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NATURE REVIEWS DISEASE PRIMERS (2015)

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Plasma isoflavone concentration is associated with decreased risk of type 2 diabetes in Korean women but not men: results from the Korean Genome and Epidemiology Study

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DIABETOLOGIA (2015)

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Article Food Science & Technology

Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial

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MOLECULAR NUTRITION & FOOD RESEARCH (2015)

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Eun-Jung Rhee

ENDOCRINOLOGY AND METABOLISM (2015)

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Immunology of Psoriasis

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Etiopathogenesis of cataract: An appraisal

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INDIAN JOURNAL OF OPHTHALMOLOGY (2014)

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Enhanced cellular uptake and anti-proliferating effect of chitosan hydrochlorides modified genistein loaded NLC on human lens epithelial cells

Wenji Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Multidisciplinary Sciences

Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

Ronald C. W. Ma et al.

YEAR IN DIABETES AND OBESITY (2013)

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Article Nutrition & Dietetics

Beneficial effect of genistein on lowering blood pressure and kidney toxicity in fructose-fed hypertensive rats

Nallasamy Palanisamy et al.

BRITISH JOURNAL OF NUTRITION (2013)

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Article Endocrinology & Metabolism

The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations The EPIC-InterAct study

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DIABETES CARE (2013)

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Editorial Material Ophthalmology

Posterior capsular opacification: A review

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INDIAN JOURNAL OF OPHTHALMOLOGY (2013)

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Article Pharmacology & Pharmacy

Design, characterization, and in vitro cellular inhibition and uptake of optimized genistein-loaded NLC for the prevention of posterior capsular opacification using response surface methodology

Wenji Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Endocrinology & Metabolism

Genistein in the Metabolic Syndrome: Results of a Randomized Clinical Trial

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JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

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Article Oncology

Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

Zhen Yang et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2012)

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Article Nutrition & Dietetics

Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes

Zhuo Fu et al.

APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME (2012)

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Article Gastroenterology & Hepatology

Nonalcoholic Fatty Liver Disease/Steatohepatitis: Epidemiology, Pathogenesis, Clinical Presentation and Treatment

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DIGESTIVE DISEASES (2012)

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Article Endocrinology & Metabolism

Osmotic stress induced oxidative damage: Possible mechanism of cataract formation in diabetes

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Review Medical Laboratory Technology

Non-alcoholic fatty liver disease

Briohny W. Smith et al.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2011)

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Article Pharmacology & Pharmacy

The soy isoflavone genistein reverses oxidative and inflammatory state, neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model

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EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

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Article Ophthalmology

Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat

Kyle A. Floyd et al.

EXPERIMENTAL EYE RESEARCH (2011)

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Review Endocrinology & Metabolism

Leaky gut and diabetes mellitus: what is the link?

S. de Kort et al.

OBESITY REVIEWS (2011)

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Review Nutrition & Dietetics

Induction of Cancer Cell Death by Isoflavone: The Role of Multiple Signaling Pathways

Yiwei Li et al.

NUTRIENTS (2011)

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Complications of cataract surgery

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CLINICAL AND EXPERIMENTAL OPTOMETRY (2010)

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Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence

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FERTILITY AND STERILITY (2010)

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Article Gastroenterology & Hepatology

Increased Fructose Consumption Is Associated with Fibrosis Severity in Patients with Nonalcoholic Fatty Liver Disease

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HEPATOLOGY (2010)

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Article Nutrition & Dietetics

Is Soy Consumption Good or Bad for the Breast?

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Article Nutrition & Dietetics

Soy Product and Isoflavone Intakes Are Associated with a Lower Risk of Type 2 Diabetes in Overweight Japanese Women

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JOURNAL OF NUTRITION (2010)

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Diabetic Cataract-Pathogenesis, Epidemiology and Treatment

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Isolation of a Human Intestinal Bacterium Capable of Daidzein and Genistein Conversion

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APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2009)

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Article Ophthalmology

Posterior Capsular Opacification A Problem Reduced but Not Yet Eradicated

Niranjan Awasthi et al.

ARCHIVES OF OPHTHALMOLOGY (2009)

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Article Chemistry, Applied

Daidzein and genestein contents in tempeh and selected soy products

Hasnah Haron et al.

FOOD CHEMISTRY (2009)

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Article Gastroenterology & Hepatology

Influence of ethnicity on histological differences in non-alcoholic fatty liver disease

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JOURNAL OF HEPATOLOGY (2009)

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Review Medicine, General & Internal

Mechanisms of Disease: Psoriasis.

Frank O. Nestle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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The key importance of soy isoflavone bioavailability to understanding health benefits

Theresa Larkin et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2008)

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Article Pharmacology & Pharmacy

Genistein inhibits aldose reductase activity and high glucose-induced TGF-β2 expression in human lens epithelial cells

Young Sook Kim et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

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Article Nutrition & Dietetics

Vegetable but not fruit consumption reduces the risk of type 2 diabetes in Chinese women

Raquel Villegas et al.

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Review Nutrition & Dietetics

Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary

Mark J. Messina et al.

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Article Dermatology

Are patients with psoriasis undertreated? Results of National Psoriasis Foundation survey

Elizabeth J. Horn et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2007)

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Review Biochemistry & Molecular Biology

Genistein - A dietary compound inducing hormonal and metabolic changes

Katarzyna Szkudelska et al.

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Article Biochemistry & Molecular Biology

The role of estrogen in the initiation of breast cancer

J. Russo et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2006)

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Review Endocrinology & Metabolism

Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: A review of the relevant literature

M Messina et al.

THYROID (2006)

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Review Medicine, Research & Experimental

Gut bacterial metabolism of the soy isoflavone daidzein: Exploring the relevance to human health

C Atkinson et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2005)

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Article Pediatrics

Soy formula complicates management of congenital hypothyroidism

SC Conrad et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2004)

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Oestrogen exposure and breast cancer risk

RC Travis et al.

BREAST CANCER RESEARCH (2003)

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Article Endocrinology & Metabolism

Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes

V Jayagopal et al.

DIABETES CARE (2002)

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Goitrogenic and estrogenic activity of soy isoflavones

DR Doerge et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2002)

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Genistein

RA Dixon et al.

PHYTOCHEMISTRY (2002)

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Soy isoflavones - Benefits and risks from nature's selective estrogen receptor modulators (SERMs)

KDR Setchell

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2001)

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Article Pharmacology & Pharmacy

Interaction of phytoestrogens with estrogen receptors α and β

K Morito et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2001)

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Article Cardiac & Cardiovascular Systems

Soy protein and cardiovascular disease - A statement for healthcare professionals from the Nutrition Committee of the AHA

JW Erdman

CIRCULATION (2000)

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Article Pharmacology & Pharmacy

Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect

HC Chang et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2000)

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