期刊
MOLECULES
卷 26, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/molecules26237280
关键词
iron-chelation; chelating agents; 3-hydroxy-4-pyridinone; Fe-complexation; Cu-interaction; sequestering ability
资金
- University of Messina [009041]
- Fundacao para a Ciencia e Tecnologia (FCT) [UID/QUI/00100/2019]
- COST (European Cooperation in Science and Technology) [CA18202]
By investigating the binding ability of bifunctional 3-hydroxy-4-pyridinones with Cu2+ and Fe3+, different speciation schemes were determined, showcasing the potential selectivity of these ligands towards Fe3+ as promising iron-chelating agents. The study also suggested that 3-hydroxy-4-pyridinones could avoid competition with essential metal cations like Cu2+ and Zn2+, making them advantageous in biological and environmental applications.
The binding ability of five bifunctional 3-hydroxy-4-pyridinones towards Cu2+ and Fe3+ was studied by means of potentiometric and UV-Vis spectrophotometric measurements carried out at I = 0.15 mol L-1 in NaCl(aq), T = 298.15 K and 310.15 K. The data treatments allowed us to determine speciation schemes featured by metal-ligand species with different stoichiometry and stability, owing to the various functional groups present in the 3-hydroxy-4-pyridinones structures, which could potentially participate in the metal complexation, and in the Cu2+ and Fe3+ behaviour in aqueous solution. Furthermore, the sequestering ability and metal chelating affinity of the ligands were investigated by the determination of pL(0.5) and pM parameters at different pH conditions. Finally, a comparison between the Cu2+ and Fe3+/3-hydroxy-4-pyridinones data herein presented with those already reported in the literature on the interaction of Zn2+ and Al3+ with the same ligands showed that, from the thermodynamic point of view, the 3-hydroxy-4-pyridinones are particularly selective towards Fe3+ and could therefore be considered promising iron-chelating agents, also avoiding the possibility of competition, and eventually the depletion, of essential metal cations of biological and environmental relevance, such as Cu2+ and Zn2+.
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