期刊
INFECTION AND IMMUNITY
卷 84, 期 4, 页码 1205-1213出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.01391-15
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资金
- Swedish Research Council [K2013 54X 09894 19 3, 2667]
- Swedish Society for Medical Research
- Sahlgrenska Center for Cardiovascular Metabolic Research (CMR) [A305: 188]
- Swedish Strategic Foundation
- EC [Full4Health FP7-KBBE-2010 - 4-266408]
- Magnus Bergvall Foundation
- Langmanska Kulturfonden
- Stiftelsen Gamla trotjanarinnor
- OE och Edla Johanssons vetenskapliga Stiftelse
- Lars Hiertas Foundation
- Ake Wiberg Foundation
- Stiftelsen Tornspiran
Sepsis caused by Staphylococcus aureus is increasing in incidence. With the alarming use of antibiotics, S. aureus is prone to become methicillin resistant. Antibiotics are the only widely used pharmacological treatment for sepsis. Interestingly, mice fed high-fat diet (HFD) rich in polyunsaturated fatty acids have better survival of S. aureus-induced sepsis than mice fed HFD rich in saturated fatty acids (HFD-S). To investigate what component of polyunsaturated fatty acids, i.e., omega-3 or omega-6 fatty acids, exerts beneficial effects on the survival of S. aureus-induced sepsis, mice were fed HFD rich in omega-3 or omega-6 fatty acids for 8 weeks prior to inoculation with S. aureus. Further, mice fed HFD-S were treated with omega-3 fatty acid metabolites known as resolvins. Mice fed HFD rich in omega-3 fatty acids had increased survival and decreased bacterial loads compared to those for mice fed HFD-S after S. aureus-induced sepsis. Furthermore, the bacterial load was decreased in resolvin-treated mice fed HFD-S after S. aureus-induced sepsis compared with that in mice treated with vehicle. Dietary omega-3 fatty acids increase the survival of S. aureus-induced sepsis by reversing the deleterious effect of HFD-S on mouse survival.
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