期刊
MOLECULES
卷 26, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/molecules26237331
关键词
carbonic anhydrase; activators; amino acid; amine; isoform selectivity; coral; protozoa; fungi; learning and cognitive impairment; neurodegenerative diseases
资金
- Italian Ministry for University and Research (MIUR) [FISR2019_04819 BacCAD, 2017XYBP2R]
After being neglected in the past, carbonic anhydrase activators (CAAs) have been proven to be useful in pharmaceutical and industrial applications, with amino acid and amine derivatives being the most explored compounds.
After being rather neglected as a research field in the past, carbonic anhydrase activators (CAAs) were undoubtedly demonstrated to be useful in diverse pharmaceutical and industrial applications. They also improved the knowledge of the requirements to selectively interact with a CA isoform over the others and confirmed the catalytic mechanism of this class of compounds. Amino acid and amine derivatives were the most explored in in vitro, in vivo and crystallographic studies as CAAs. Most of them were able to activate human or non-human CA isoforms in the nanomolar range, being proposed as therapeutic and industrial tools. Some isoforms are better activated by amino acids than amines derivatives and the stereochemistry may exert a role. Finally, non-human CAs have been very recently tested for activation studies, paving the way to innovative industrial and environmental applications.
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